75 citations
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January 2014 in “Korean Journal of Urology” 5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.
67 citations
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September 2008 in “Dermatologic therapy” Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.
59 citations
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April 2016 in “Breast Cancer Research and Treatment” Targeting vitamin D and androgen receptors may effectively treat triple-negative breast cancer, especially with chemotherapy.
58 citations
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November 2020 in “International Journal of Molecular Sciences” SHBG may be a useful early indicator and treatment target for PCOS.
57 citations
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February 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.
49 citations
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November 2019 in “Egyptian Journal of Medical Human Genetics” Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.
45 citations
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February 2005 in “Steroids” Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.
38 citations
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December 2009 in “Therapeutic Advances in Medical Oncology” The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.
37 citations
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June 2021 in “Journal of the European Academy of Dermatology and Venereology” Adult skin quickly reacts to short-term environmental and internal stress, leading to various skin issues and the need for protective measures.
37 citations
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November 1995 in “Journal of Investigative Dermatology” Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
32 citations
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January 2018 in “American Journal of Clinical Dermatology” Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.
29 citations
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May 2010 in “Annals of Pharmacotherapy” Finasteride may help some women with hair loss, but better options exist.
29 citations
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October 1988 in “Journal of Steroid Biochemistry” Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.
23 citations
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July 2003 in “Pharmacology, Biochemistry and Behavior” Finasteride blocks progesterone's effect on absence seizures in rats.
20 citations
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February 2004 in “Veterinary dermatology” Dog hair grows back in about 14 weeks after being clipped for surgery, and the season doesn't really affect this growth rate.
17 citations
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January 2006 in “Veterinary Dermatology” Topical melatonin and brushing did not affect hair regrowth in Siberian Huskies.
16 citations
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September 2018 in “Clinical Biochemistry” The document concludes that more research is needed to fully understand the causes of PCOS.
15 citations
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December 2021 in “Nature Communications” Androgens in female meerkats influence aggression and dominance, affecting social dynamics and offspring behavior.
14 citations
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May 2008 in “Journal of proteome research” Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.
12 citations
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October 1995 in “The Journal of Clinical Endocrinology & Metabolism” Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.
10 citations
,
October 2018 in “Sexual medicine reviews” Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.
9 citations
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November 2018 in “Acta Clinica Belgica” Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.
8 citations
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March 2019 in “Drugs - Real World Outcomes” Healthcare claims databases can help monitor drug safety, but may report adverse events differently than direct surveillance.
8 citations
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May 1996 in “Endocrinology” Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.
7 citations
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April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology” 11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
6 citations
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February 2009 in “Veterinární Medicína” Deslorelin effectively treats hair loss in neutered ferrets by reducing hormone levels.
6 citations
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January 1996 in “Endocrine-related Cancer” Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.
5 citations
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October 2018 in “Sains Malaysiana” Testosterone reduces key molecules needed for early pregnancy in rats.
3 citations
,
December 2021 in “Physiological Research” Low testosterone may increase COVID-19 severity in men.
3 citations
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February 2018 in “Journal of evolution of medical and dental sciences” Some ovarian tumors can cause masculinization, and it's important to check for various causes when this symptom is present.