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GlossaryAndrogenetic Alopecia

genetic hair loss influenced by androgens, often hereditary

Androgenetic Alopecia, commonly known as Male Pattern Baldness or Female Pattern Baldness, is a genetic condition characterized by progressive hair thinning and loss. It is influenced by androgens (male hormones) and typically follows a recognizable pattern, such as a receding hairline in men and diffuse thinning on the crown in women. This condition is the most common cause of hair loss, affecting both genders, and is often hereditary.

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research Divergent progression pathways in male androgenetic alopecia and female pattern hair loss: Trichoscopic perspectives

January 2024 in “Journal of Cosmetic Dermatology”

Men's and women's pattern hair loss progress differently, with men showing more hair thinning and women having more widespread hair loss.

Progression of Hair Loss in Men With Androgenetic Alopecia: Long-Term Controlled Observational Data in Placebo-Treated Patients

research Progression of hair loss in men with androgenetic alopecia (male pattern hair loss): long-term (5-year) controlled observational data in placebo-treated patients.

9 citations , December 2008

Men with untreated male pattern hair loss continue to lose hair over a 5-year period.

research Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia

8 citations , June 2019 in “Scientific Reports”

Increased PPARGC1α relates to hair thinning in common baldness.

research Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression

12 citations , May 2016 in “British Journal of Dermatology”

AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.

Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

research Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

11 citations , September 1997 in “Archives of Dermatology”

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

research Can we halt male androgenetic alopecia progression without antiandrogenic drugs?

1 citations , December 2019 in “Dermatologic Therapy”

Only anti-androgenic drugs likely halt AGA progression.

The Role of 5-Alpha-Reductase Inhibition in Suppressing Progression of Male Androgenetic Alopecia and the Potential Application of Saw Palmetto Extracts

research The role of 5-α-reductase inhibition in supressing progression of male androgenetic alopecia − a postulate for further studies on possible application of saw palmetto extracts

October 2023 in “Annales Academiae Medicae Silesiensis”

Saw palmetto extracts might help treat male hair loss and need more research.

research Oral cyclosporin does not arrest progression of androgenetic alopecia.

1 citations , November 2001 in “British Journal of Dermatology”

Oral cyclosporin doesn't stop hair loss.

research Oral cyclosporin does not arrest progression of androgenetic alopecia

July 2008 in “British Journal of Dermatology”

Cyclosporin doesn't stop hair loss.

research Causal Mechanism of Progressive Androgenetic Alopecia

January 1996

research Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men

21 citations , July 2014 in “British Journal of Dermatology”

Hair thickness matters more than density for baldness in Japanese men over 25.

Androgenetic Alopecia: Modeling Progression and Regrowth

research Androgenetic alopecia. Modelling progression and regrowth

4 citations , April 2016 in “Experimental Dermatology”

AGA causes hair loss through follicle miniaturization and hair cycle changes; regrowth depends on anagen initiation in kenogen follicles.

Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

research Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells

3 citations , February 2022 in “Frontiers in Genetics”

The LncRNA AC010789.1 slows down hair loss by promoting hair follicle growth and interacting with miR-21 and the Wnt/β-catenin pathway.

Platinum Nanozyme-Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment

research Platinum Nanozyme‐Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment

October 2024 in “Small Methods”

Platinum nanozyme microneedles can effectively and safely promote hair growth for androgenetic alopecia.

research Age-Related Progression of Androgenetic Alopecia: Statistical Analysis in 5,372 Japanese Men

July 2024 in “JAAD International”

Psychological Stress Impact on Neurotrophic Factor Levels in Patients With Androgenetic Alopecia and Correlation With Disease Progression

research Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression

October 2024 in “World Journal of Psychiatry”

Stress worsens hair loss in androgenetic alopecia.

research The Effect of a Food Supplement and a Hair Lotion on the Progression of Androgenetic Alopecia

2 citations , January 2019 in “Journal of Cosmetics, Dermatological Sciences and Applications”

The supplement and lotion significantly reduced hair loss and improved hair health.

research Assessment of The Influence of Non-Genetic Risk Factors on The Disease Onset and Progression of Androgenetic Alopecia in Egyptian Males

October 2021 in “QJM: An International Journal of Medicine”

Avoiding smoking, stress, obesity, and poor diet may help reduce hair loss in young Egyptian males.

Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia

research Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia

May 2025 in “Journal of Inflammation Research”

Natural killer and CD8+ T cells play a key role in hair loss in androgenetic alopecia.

Correction to 'Divergent Progression Pathways in Male Androgenetic Alopecia and Female Pattern Hair Loss: Trichoscopic Perspectives'

research Correction to “Divergent progression pathways in male androgenetic alopecia and female pattern hair loss: Trichoscopic perspectives”

June 2024 in “Journal of cosmetic dermatology”

The document corrects errors in a table about hair loss in women.

Androgenetic Alopecia: A Possible Treatment and Relationship with Hair Greying. Assessment of the Herbal Mixture Xiantene for the Treatment of Androgenetic Alopecia and Its Relationship with Early Hair Greying

research Androgenetic alopecia: a possible treatment and a relationship with hair greying. Assessment of the herbal mixture Xiantene for the treatment of androgenetic alopecia and a relationship between early hair greying and the progression of androgenetic alopecia

January 2010

The herbal mixture Xiantene may help treat common baldness, and men who grey early tend to be less bald but more grey.

research Increased scalp skin and serum 5 alpha-reductase reduced androgens in a man relevant to the acquired progressive kinky hair disorder and developing androgenetic alopecia

2 citations , September 1997 in “Archives of Dermatology”