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Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

Blocking a certain signal in the gp130 receptor can improve tissue healing and lessen osteoarthritis symptoms.

Some synthesized compounds were more effective than Finasteride in reducing prostate cancer cell growth and androgen levels.

Combining dutasteride or finasteride with an α1 blocker is more effective for managing BPH than using either alone.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Dutasteride may help protect neurons and reduce inflammation in Parkinson's disease.

Finasteride may affect male fertility by interfering with specific sperm signaling.

The new saw palmetto extract effectively inhibits an enzyme linked to prostate enlargement and may be as good as standard treatments.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Gene expression differences in PFS patients suggest a potential organic cause for symptoms.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

LX-38 is a safer drug option for treating prostate issues and hair loss without hormonal side effects.

The research helps understand how finasteride works and aids drug development.

Finasteride treatment lowers urine androgen and prostaglandin levels, making them potential markers for effectiveness.

Progesterone helps protect against stress-related memory and behavior issues in rats.

The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

High levels of certain fats in rapeseed oil can reduce the skin's ability to produce prostaglandin E2 and cause hair loss and skin issues in rats.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Paeoniflorin protects brain cells by involving a specific protein and neurosteroids.

Chemoprevention can significantly lower cancer risks and needs more research and collaboration.

GPR40 agonists help hair growth through the protein ANGPTL4.

PM-9 and finasteride effectively inhibit the enzyme that converts testosterone to DHT.

5α-reductases increase epitestosterone's effect on androgen receptors.

SARMs may offer benefits by boosting muscle effects without unwanted side effects.

5-Alpha reductase inhibitors help treat enlarged prostate but may cause sexual side effects.

Blocking progesterone metabolism can cause depression-like behavior in mice.