April 2019 in “Molecular Informatics” Researchers developed reliable models to predict how well certain compounds bind to androgen receptors, emphasizing the importance of atomic electronegativity.
April 2017 in “Austin Journal of Cancer and Clinical Research” 5α-reductase inhibitors like Finasteride and Dutasteride may help manage prostate cancer by blocking testosterone conversion.
Finasteride causes reproductive malformations in male rats.
November 2010 in “Value in Health” Treating chronic hand eczema costs about the same in statutory and occupational health insurances in Germany, but work-related cases may lead to higher indirect costs due to longer work absences.
November 2010 in “Value in Health” Cataract surgery guidelines vary across Europe, and generic finasteride sales for hair loss have grown due to pill splitting.
November 2010 in “Value in Health” Cataract surgery in Europe varies in frequency and cost between countries.
November 2010 in “Value in Health” Using a call center to collect data in a trial for eye disease in diabetics led to high response rates and very little missing information.
March 2009 in “The Journal of Urology” Shorter PSADT after prostate surgery is linked to higher risk of death.
October 2008 in “The Journal of Urology” Finasteride reduces prostate cancer risk but may increase high-grade tumors and has side effects; biopsy methods have similar outcomes; psychosocial factors affect sexual recovery post-surgery.
July 2007 in “Journal of Reproduction & Infertility” Short-term finasteride use likely doesn't harm male fertility.
January 2007 in “El Servicio de Difusión de la Creación Intelectual (National University of La Plata)” Combining D-004 and finasteride is more effective at reducing prostate enlargement than using either alone.
November 2020 in “Reactions Weekly” Finasteride use linked to increased suicidality in patients under 45.
October 2020 in “Journal of Pharmaceutical Sciences” Topical finasteride with EGCG or TA improves drug release and dermal uptake, potentially treating hair loss effectively.
October 2020 in “Journal of Pakistan Association of Dermatology” Finasteride appears safe for long-term sperm concentration, but more research is needed for clear conclusions.
June 2017 in “Reactions Weekly” Finasteride (Propecia) may cause depression and suicidal thoughts; stop use and inform a healthcare professional if symptoms develop.
June 2001 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” Finasteride improves hair growth in men with androgenetic alopecia.
56 citations
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February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
Saw palmetto is not proven to improve urinary flow, prostate size, or hair loss.
3 citations
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October 1993 in “Endocrinology”
195 citations
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February 2007 in “The Journal of Clinical Endocrinology and Metabolism” Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
195 citations
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June 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
155 citations
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December 2003 in “British Journal of Dermatology” Hair loss increases with age; alcohol raises risk, more female partners lowers it.
127 citations
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May 2004 in “PubMed” Finasteride may help some male chronic pelvic pain patients, but more research needed.
124 citations
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March 2012 in “JAMA” Testosterone's muscle-building effects do not require its conversion to DHT.
124 citations
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January 1993 in “The Prostate” Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.
123 citations
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May 2020 in “Drug Development Research” Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.
105 citations
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January 2004 in “The Journal of Urology” Finasteride improves chronic pelvic pain, saw palmetto doesn't.
104 citations
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October 1999 in “The Journal of Urology” Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.
99 citations
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October 2006 in “BMC clinical pharmacology” Finasteride may cause slight depression and anxiety.
98 citations
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April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively blocks rat enzymes, but with varying methods and strength.