30 citations
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June 2010 in “Endocrine Related Cancer” SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.
30 citations
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June 1988 in “Journal of Steroid Biochemistry” Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.
28 citations
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August 2011 in “Journal of The American Academy of Dermatology” Early hair loss may indicate prostate issues.
26 citations
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May 2012 in “Cellular and Molecular Life Sciences” NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.
20 citations
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January 2017 in “Nutrition Research and Practice” Corn silk extract helps reduce prostate enlargement symptoms.
20 citations
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March 2021 in “Cancers” Certain genetic variants increase the risk of aggressive prostate cancer.
20 citations
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August 2020 in “Scientific Reports” Low-dose bisphenol A increases prostate size in rats by affecting certain enzymes.
18 citations
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May 2020 in “Biomolecules” Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.
16 citations
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January 2003 in “Nuclear Receptor Signaling” Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.
16 citations
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August 2021 in “Tumor Biology” TMPRSS2 helps viruses enter cells and protects the prostate from inflammation-related cancer.
16 citations
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October 2007 in “Andrologia” DHT is a strong androgen that may pose less risk to the prostate compared to testosterone.
16 citations
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October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology” Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
15 citations
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January 2017 in “Advances in Experimental Medicine and Biology” 5α-Reductase inhibitors can negatively affect male sexual function and, in some cases, significantly reduce sperm count, but these effects may be reversible.
13 citations
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January 2005 in “Chemical and Pharmaceutical Bulletin” Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.
12 citations
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January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” Negative expectations can cause adverse effects in dermatology treatments, like with finasteride for baldness, and careful communication can help reduce these nocebo responses.
11 citations
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September 2021 in “Journal of molecular endocrinology” ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.
11 citations
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June 2020 in “Biomedicines” % free PSA and urinary markers help better identify prostate cancer.
9 citations
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July 2024 in “Toxins” OnabotulinumtoxinA is used to treat wrinkles, pain, sweating, hair loss, and more by temporarily paralyzing muscles and affecting pain pathways.
9 citations
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June 2018 in “Scientific Reports” People with certain types of alopecia have a slightly higher risk of cancer, especially thyroid, bladder, and prostate cancers.
8 citations
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November 2019 in “Dermatologic Clinics” AGA treatments like minoxidil and LLLLT are safe and effective for gender minority patients.
8 citations
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May 2011 in “Journal of Pharmacology and Experimental Therapeutics” Dosing time affects finasteride's effectiveness and safety in rats.
8 citations
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February 2010 in “Journal of Dermatology” A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.
8 citations
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October 1998 in “Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology” Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.
8 citations
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May 1982 in “Journal of Endocrinology/Journal of endocrinology” Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.
7 citations
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August 2019 in “Bioorganic & medicinal chemistry” Analog 23 is a promising compound for prostate cancer treatment.
7 citations
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May 2016 in “European Polymer Journal” The new nanocarriers improve how well water-insoluble drugs dissolve and allow for controlled drug release.
7 citations
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January 2016 in “British Journal of Cancer” Men with certain types of baldness at age 45 may have a higher risk of colon cancer and colorectal adenoma.
5 citations
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February 2022 in “Supportive Care in Cancer” Older age is the main risk factor for hemorrhagic cystitis after stem cell transplants.
5 citations
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September 2012 in “The Journal of Urology” Early hair loss may indicate future prostate issues.
5 citations
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April 2011 in “Bioorganic & Medicinal Chemistry Letters” New Finasteride conjugate improves prostate treatment and vital signs in rats.