The Secret Identities of TMPRSS2: Fertility Factor, Virus Trafficker, Inflammation Moderator, Prostate Protector and Tumor Suppressor

The document explored the diverse roles of the TMPRSS2 gene, particularly its involvement in prostate cancer, male fertility, and viral infections like SARS-CoV-2. TMPRSS2 facilitated viral entry and was implicated in inflammation modulation, acting as a tumor suppressor in the prostate. It was often involved in TMPRSS2:ERG gene fusions, common in prostate cancer, which could exacerbate cancer progression. While TMPRSS2 inhibitors might reduce viral infectivity, caution was advised against their use in cancer treatment due to potential adverse effects on inflammation. The document highlighted the need for further research to understand TMPRSS2's molecular targets and its role in prostate cancer and male infertility.