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Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

New sulfur-containing steroid analogs show promise for more targeted medical treatments.

Using finasteride with TIP extends time off period for prostate cancer patients.

Testosterone may influence COVID-19 severity and outcomes.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Liquorice may reduce testosterone and affect male reproductive organs, potentially helping treat conditions like prostate cancer.

A new method was developed to make finasteride for treating hair loss.

5ARIs like finasteride can help prevent prostate cancer and treat BPH, but guidelines should be updated to reflect this.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Omega-6 fats in certain cells boost male hormone production.

Balding and low testosterone increase risk of urinary stones.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

Dutasteride reduces hospitalization and prostate cancer risk compared to finasteride, potentially offsetting its higher cost.

Off-label drug use can be risky and requires careful consideration to ensure patient safety.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

5ARIs lower PSA levels, but other tests are needed to avoid missing aggressive prostate cancer.

Finasteride may cause breast enlargement, low testosterone a risk factor.

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

Piper cubeba and Aquilaria sinensis may help prevent or treat prostate issues by balancing hormones.

Finasteride and dutasteride may lower melanoma risk, with teenage acne possibly indicating higher risk.

A new compound was made that might help treat diseases related to male hormones.

Systematic end-of-trial biopsies are the most reliable way to assess outcomes.

Dutasteride showed some prevention of prostate issues but also had limitations, especially with high-grade tumors.

Finasteride improves prostate cancer prediction by adjusting kallikrein marker levels.

Finasteride lowers PSA levels and prostate size, requiring adjusted PSA interpretation for accurate cancer screening.