14 citations
,
April 2016 in “British Journal of Dermatology” The study found that the most common repigmentation pattern in children with vitiligo is a combination of patterns, with a new medium spotted pattern identified.
17 citations
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April 2002 in “Contact Dermatitis” Minoxidil 5% caused skin discoloration in a man using it for hair loss.
119 citations
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May 1987 in “The Journal of Dermatologic Surgery and Oncology” Most patients' skin darkening after sclerotherapy fades on its own within 6-24 months.
60 citations
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January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Applying a specific inhibitor lightens skin and hair color.
73 citations
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October 2003 in “Journal of Pharmacology and Experimental Therapeutics” Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.
12 citations
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June 2010 in “Journal of dermatology” Some patients with severe alopecia areata developed skin darkening from their treatment, which may indicate a less effective response to the therapy.
4 citations
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March 2020 in “JAAD Case Reports” Vitamin B12 deficiency can cause darkening of all nails.
September 2012 in “British Small Animal Veterinary Association eBooks” The document concludes that pigmentation disorders in animals involve complex interactions between melanocytes and keratinocytes.
1 citations
,
January 2013 in “Nasza Dermatologia Online” Vitamin B12 deficiency can cause reversible hair color loss in children.
August 2025 in “Annals of Medicine” Mycophenolate mofetil may safely help restore skin color in depigmentation conditions.
44 citations
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April 1979 in “Journal of Ultrastructure Research” 1 citations
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September 2017 in “BMJ” The man has a disease causing skin patches, thickened nerves, and mild muscle weakness.
1 citations
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January 2014 in “Elsevier eBooks” Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.
1 citations
,
January 2014 in “International Journal of Trichology” A patient with a rare hair condition and skin disorder showed hair improvement after treatment.
2 citations
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January 2002 in “Clinics in Dermatology” Vitiligo causes white skin patches, often starts before age 20, and is linked to other health issues.
2 citations
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January 2019 in “Springer eBooks” Segmental Vitiligo is a stable, early-onset form of vitiligo that responds well to early treatment and is ideal for repigmentation studies.
41 citations
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June 2010 in “Journal of Investigative Dermatology” New cells are added to the hair's dermal papilla during the active growth phase.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a new way UVB light increases skin pigmentation through the ATP-P2X7 pathway.
1 citations
,
January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” Increased PHGDH expression causes early melanin buildup in hair follicles.
January 2023 in “Indian Dermatology Online Journal” Micropigmentation is a cosmetic tattooing technique for hiding skin issues and creating permanent makeup, but it can have side effects.
June 2017 in “Journal of the American Academy of Dermatology” Plucked hair can help diagnose pemphigus vulgaris early.
November 2025 in “Journal of Investigative Dermatology” Tanning ability is linked to specific DNA changes in skin genes.
31 citations
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November 2015 in “PloS one” Reducing Tyrosinase prevents mature color pigment cells from forming in mouse hair.
2 citations
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January 2002 Melanin and melanocytes contribute to the brown pigmentation in stasis dermatitis.
9 citations
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June 1959 in “Archives of dermatology” Hair can darken after inflammation and then return to its original color.
37 citations
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October 2017 in “Advanced drug delivery reviews” The review suggests that there are various treatments to help restore skin color after severe burns.
2 citations
,
August 1987 in “Archives of Dermatology” Langerhans' cells are not responsible for depigmentation in this mouse model.
6 citations
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January 2015 in “Indian Dermatology Online Journal” PEODDN is a rare skin disorder with limited treatment options, best treated with laser therapy.
15 citations
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January 2013 in “Dermatologic Surgery” Epithelial grafting can effectively repigment white hair in vitiligo patients.
16 citations
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July 2016 in “Journal of Dermatological Science” Regenerated hairs can regain their color if the wound occurs during a certain stage of hair growth, and this process is helped by specific skin cells and proteins.