research Gleason grading controversies: what the chemoprevention trials have taught us
Finasteride reduces prostate cancer risk by 30% without affecting Gleason scores.
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research Comparison of Finasteride and Dutasteride on Risk of Prostate Cancer in Patients with Benign Prostatic Hyperplasia: A Pooled Analysis of 15 Real-world Databases
Dutasteride and finasteride have similar effects on prostate cancer risk in BPH patients.
research ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts
The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
research Should Finasteride Be Routinely Given Preoperatively for TURP?
Finasteride may reduce bleeding after TURP, but more research needed.
research Heavy metals in biological samples of cancer patients: a systematic literature review
Heavy metals like arsenic, cadmium, and lead can increase cancer risk and worsen outcomes.
research A Review: Proteins Involved in the Major Symptoms of Polycystic Ovarian Syndrome
Understanding proteins linked to PCOS symptoms can improve diagnosis and treatment.
research Relación entre los síntomas del tracto urinario bajo y las características anatómicas de la próstata en pacientes con obesidad y obesidad grave
Obesity is linked to more severe lower urinary tract symptoms.
research 5α- Reductase Inhibitors in Prostate Cancer: An Overview
5α-reductase inhibitors like Finasteride and Dutasteride may help manage prostate cancer by blocking testosterone conversion.
research Hair Restoration
The document concludes that there are various causes and treatments for hair loss, with hair transplantation being a notable option.
research What do we know about phytotherapy of benign prostatic hyperplasia?
Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.
research S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents
Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.
research Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men
Minoxidil and finasteride can slow hair loss and stimulate regrowth, but won't restore all lost hair or reverse complete baldness.
research Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
A new genetic region, 17q21.31, is linked to higher ovarian cancer risk.
research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia
Oral finasteride works better than topical minoxidil for hair growth, both are safe.
research Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?
PPAR agonists show promise for skin conditions but need more research before being a main treatment.
research Pattern Hair Loss in Men
Male pattern hair loss caused by follicular miniaturization; early diagnosis and treatment can reduce psychological burden.
research Redefining hormone resistance in prostate cancer
The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.
research Enhanced remyelination during late pregnancy: involvement of the GABAergic system
Late pregnancy helps repair brain damage in rats due to the GABAergic system.
research A population‐based nested case–control study: the use of 5‐alpha‐reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia
Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.
research Is COVID-19 a risk factor for progression of benign prostatic hyperplasia and exacerbation of its related symptoms?: a systematic review
COVID-19 might worsen symptoms and progression of benign prostatic hyperplasia, possibly due to inflammation and metabolic disturbances in the prostate gland. More research is needed to confirm this.
research The antiandrogenic effect of finasteride against a mutant androgen receptor
Finasteride may improve prostate cancer treatment outcomes.
research The endocrinology of baldness
Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.
research Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment
Long-term use of dutasteride can cause permanent erectile dysfunction in rats.
research Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach
New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.
research Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells
Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.
research Under Development JAK Inhibitors for Dermatologic Diseases
New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.
research Gut microbiota in alopecia areata
Alopecia areata may be linked to imbalanced gut bacteria.
research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases
New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
research Oral administration of berberine represses macrophage activation-associated benign prostatic hyperplasia: a pivotal involvement of the NF-κB
Berberine may reduce prostate enlargement by blocking inflammation.
research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro
11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.