2 citations
,
September 2021 in “Human Psychopharmacology: Clinical and Experimental” Valproate can cause hair problems, but there are ways to manage them.
16 citations
,
May 2009 in “Journal of child neurology” Valproic acid does not change biotinidase enzyme activity in children's blood.
26 citations
,
November 2016 in “European Journal of Clinical Pharmacology” Valproic acid helps delay hair loss and increases survival time for high-grade glioma patients undergoing radiation therapy.
January 2004 in “Headache” Divalproex sodium significantly improved headaches in two-thirds of patients.
July 2023 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ” Antiandrogens help improve developmental delays caused by valproic acid in rats.
36 citations
,
October 2008 in “European journal of paediatric neurology” Valproic acid treatment may cause temporary hair loss due to reduced zinc and biotinidase levels, which tend to normalize after 6 months.
29 citations
,
March 1987 in “Therapeutic Drug Monitoring” Combining sodium valproate with other epilepsy drugs increases ammonia levels and side effects.
20 citations
,
December 2011 in “Journal of inherited metabolic disease” Valproic acid treatment increases a specific acid in urine by blocking an enzyme, possibly causing skin rash and hair loss.
2 citations
,
September 2015 in “Türk pediatri arşivi : İstanbul çocuk kliniği dergisi” Valproic acid can very rarely cause nail separation, which usually gets better on its own after stopping the drug.
7 citations
,
September 2007 Valproate sustained-release is effective and generally safe for short-term treatment of new partial epilepsy.
5 citations
,
June 2012 in “PubMed” Valproic acid can cause a skin condition called leukocytoclastic vasculitis, which usually gets better after stopping the drug.
6 citations
,
April 2013 in “International Journal of Dermatology” Valproic acid helped hair growth in alopecia patient; more research needed.
5 citations
,
August 2018 in “European Psychiatry” Some psychiatric drugs can cause severe hair loss, especially valproic acid, and it's more likely in women or those with thyroid issues or past hair loss.
73 citations
,
October 2001 in “Epilepsia” Children taking higher doses of valproic acid had lower biotinidase activity, which may lead to biotin deficiency, but biotin supplements could help.
64 citations
,
March 1989 in “PubMed” Valproate is effective for epilepsy but has side effects and requires careful monitoring.
5 citations
,
January 2017 in “Nevrologiâ, nejropsihiatriâ, psihosomatika” Sustained-release sodium valproate is effective in treating epilepsy, with some side effects influenced by genetics.
June 2021 in “Clinical neuropsychopharmacology and therapeutics” Valproic acid can cause hair color change in older men.
47 citations
,
March 2019 in “Journal of immunology research” Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.
February 2023 in “Indian journal of private psychiatry/Indian Journal of Private Psychiatry” Valproic acid can rarely cause reversible nail discoloration.
January 2026 in “Open Science Framework” More research is needed to find effective treatments for hair loss caused by valproic acid.
January 2025 in “Seizure” Dual anti-seizure medications, especially valproic acid with lamotrigine, often cause more side effects like hair loss and memory issues.
January 2024 in “Specialty journal of Pharmacognosy Phytochemistry and Biotechnology” Genetic factors may influence how well valproic acid works and its side effects in epilepsy treatment.
9 citations
,
January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” Higher doses of the medication valproate can cause hair loss, which may stop when the dose is lowered or the medication is stopped.
3 citations
,
October 1976 in “BMJ” Sodium valproate can cause low platelets and hair loss.
20 citations
,
August 1981 in “Developmental Medicine & Child Neurology” 13 citations
,
June 1981 in “Developmental Medicine & Child Neurology” 4 citations
,
October 2015 in “JAAD Case Reports” Surgical grafting may fix nail issues caused by valproic acid.
2 citations
,
September 2014 in “International Journal of Dermatology” Sodium valproate can worsen psoriasis-like skin conditions.
15 citations
,
May 2006 in “Brain & development” Valproic acid may cause hair loss by reducing biotinidase enzyme activity in rats.
68 citations
,
March 2018 in “Biomaterials” Tiny needles with valproic acid can effectively regrow hair.