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Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

research Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

5 citations , September 2021 in “Frontiers in Cell and Developmental Biology”

Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

26 citations , June 2003 in “PubMed”

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.

research Adverse events related to platelet-rich plasma therapy and future issues to be resolved

44 citations , June 2024 in “Regenerative Therapy”

PRP therapy may cause infections and other issues, needing more research for safety.

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

VEGF promotes hair follicle cell growth through the VEGFR-2/ERK pathway.

research ANALYSIS OF THE BACKGROUND LEVEL OF CYTOKINES M1 AND M2 OF THE MACROPHAGE PHENOTYPE IN PATIENTS WITH REVISION RHINOPLASTY AFTER THE USE OF THE DRUG PDRN

January 2025 in “Fìzìologìčnij žurnal”

PDRN may reduce inflammation and complications in revision rhinoplasty for patients with high fibrinogen levels.

research Reduced levels of 5-α reductase 2 in adult prostate tissue and implications for BPH therapy

39 citations , February 2011 in “The Prostate/The prostate”

Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.

research Olmsted Syndrome Caused by a Homozygous Recessive Mutation in TRPV3

56 citations , January 2014 in “Journal of Investigative Dermatology”

Olmsted syndrome can be inherited as an autosomal recessive trait due to a rare TRPV3 gene mutation.

research Potential PRP Hair Treatment Side Effects

February 2017

PRP hair treatment is generally safe but may cause minor pain, bleeding, redness, and scalp tightness, and isn't suitable for everyone.

research TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles

7 citations , January 2016 in “Laboratory Investigation”

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

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