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GlossaryPuberty Blockers

medications that delay the physical changes of puberty

Puberty blockers, also known as puberty inhibitors or hormone blockers, are medications that delay the physical changes associated with puberty. They work by suppressing the release of sex hormones like estrogen and testosterone, which can be particularly beneficial for transgender and non-binary youth who need more time to explore their gender identity before undergoing irreversible physical changes. These medications are also used in cases of precocious puberty to prevent early onset of puberty.

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research Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical Practice Guideline

855 citations , June 2009 in “The Journal of Clinical Endocrinology & Metabolism”

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

research Clinical Management of Youth with Gender Dysphoria in Vancouver

116 citations , December 2013 in “The Journal of Pediatrics”

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

research Progress on the road to better medical care for transgender patients

66 citations , October 2013 in “Current Opinion in Endocrinology, Diabetes and Obesity”

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

research Endocrine care of transpeople part I. A review of cross-sex hormonal treatments, outcomes and adverse effects in transmen

45 citations , March 2015 in “Clinical Endocrinology”

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

research Gonadal Suppressive and Cross‐Sex Hormone Therapy for Gender Dysphoria in Adolescents and Adults

25 citations , September 2014 in “Pharmacotherapy”

Hormone therapy can improve mental health and quality of life for people with gender dysphoria, but long-term effects need more research.

research Hormone Treatment for the Adult Transgender Patient

1 citations , January 2020 in “Elsevier eBooks”

Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

research An affirming approach to caring for transgender and gender-diverse youth

October 2023 in “Paediatrics & child health”

The document advises health care providers on how to support transgender and gender-diverse youth with appropriate care and referrals.

Medical Care for Children and Adolescents with Gender Dysphoria and Gender Inconsistency in Light of Current Recommendations: How to Implement the 'Primum Non Nocere' Principle?

research Medical care for children and adolescents with gender dysphoria and gender inconsistency in the light of current recommendations - how to implement the "primum non nocere" principle?

September 2023 in “Fides et Ratio”

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

research Dermatological care of gender‐diverse patients in Australia

August 2024 in “Australasian Journal of Dermatology”

Australia needs better dermatological guidelines for gender-diverse patients.

research Androgenetic alopecia: An autosomal dominant disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research [Hidradenitis suppurativa - symptoms, diagnostics, and therapy].

2 citations , April 2019 in “PubMed”

Hidradenitis suppurativa is a chronic skin condition causing painful lumps and scarring, often triggered by smoking and obesity, and requires varying treatments based on severity.

Delayed Puberty: Diagnosis and Management of Congenital Idiopathic Hypogonadotropic Hypogonadism

research Delayed Puberty

January 2016 in “Springer eBooks”

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

research Adverse effects of common medications on male fertility

77 citations , June 2015 in “Nature Reviews Urology”

Some common medications can harm male fertility, but many effects can be reversed.

research Therapeutic Androgen Receptor Ligands

16 citations , January 2003 in “Nuclear Receptor Signaling”

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque¹

33 citations , January 1997 in “Endocrinology”

Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.

research Endocrinology of Transgender Medicine

166 citations , October 2018 in “Endocrine Reviews”

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Chronic Inflammatory Diseases Stimulated by Current Lifestyle: How Diet, Stress Levels, and Medication Prevent Our Body from Recovering

research Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering

119 citations , January 2012 in “Nutrition & Metabolism”

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

research Hormonal treatment of acne vulgaris: an update

46 citations , September 2016 in “Clinical, Cosmetic and Investigational Dermatology”

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

research Hormonal therapies for acne

26 citations , October 2016 in “Clinics in Dermatology”

Hormonal treatments can improve acne, but they come with potential side effects and risks.

research Androgenic disorders of women: Diagnostic and therapeutic decision making

17 citations , January 1995 in “The American Journal of Medicine”

The document concludes that proper diagnosis and tailored long-term treatment can effectively manage androgenic disorders in women, improving patient care outcomes.

research Anti-androgen therapy in dermatology: a review

5 citations , December 1979 in “Clinical and Experimental Dermatology”

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

research Acne: Hormonal concepts and therapy

118 citations , September 2004 in “Clinics in Dermatology”

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Nonclassic Adrenal Hyperplasia: Clinical Features, Diagnosis, and Treatment

research Nonclassic adrenal hyperplasia

55 citations , August 2008 in “Reviews in endocrine and metabolic disorders”

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

research Skin Conditions in Figure Skaters, Ice-Hockey Players and Speed Skaters

48 citations , October 2011 in “Sports Medicine”

Ice-skating athletes often have skin problems due to cold, infections, and inflammation, needing careful treatment and prevention.

research Endocrine-skin interactions

46 citations , July 1988 in “Journal of The American Academy of Dermatology”

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

research Hormone therapy in acne

24 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

research Treatment of androgen excess in females: Yesterday, today and tomorrow

9 citations , January 1997 in “Gynecological Endocrinology”

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

research Hidradenitis Suppurativa/Acne Inversa/Dissecting Terminal Hair Folliculitis

1 citations , January 2019 in “Springer eBooks”

Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.

research Hormonal Therapy for Acne

1 citations , November 1996 in “Journal of Cutaneous Medicine and Surgery”

Hormones, especially androgens, play a key role in causing acne, and treatments like hormone control pills and hormone-blocking medications can help.

research Testosterone therapy in men: Clinical and pharmacological perspectives

25 citations , March 2000 in “Journal of Endocrinological Investigation”

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.