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research Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol–response curve in porcine detrusor muscle

3 citations , March 2012 in “Arab Journal of Urology”

Certain drugs can reduce bladder muscle contractions, potentially helping treat bladder diseases.

research An anti‐hair loss treatment in the management of mild androgenetic alopecia: results from a large, international observational study

1 citations , September 2021 in “Dermatologic Therapy”

AC5 improves hair loss and hair quality with high satisfaction rates.

research Leflunomide-Induced Cutaneous Ulcers: A Rare Diagnostic Conundrum

May 2026 in “Indian Dermatology Online Journal”

Leflunomide can cause skin ulcers, and stopping it can lead to healing.

research 458 UVB-induced facultative pigmentation is associated with distinct DNA methylation changes

November 2025 in “Journal of Investigative Dermatology”

Tanning ability is linked to specific DNA changes in skin genes.

Chitosan and Its Amphiphilic Derivative Nanoparticles Loaded with Minoxidil for Induction of Hair Growth: In Vitro and In Vivo Evaluation

research Chitosan and its amphiphilic derivative nanoparticles loaded with Minoxidil for induction of hair growth: In vitro and in vivo evaluation

December 2023 in “International Journal of Biological Macromolecules”

Chitosan nanoparticles loaded with Minoxidil were effective for hair growth but released the drug more slowly than the amphiphilic derivative.

Application of Validated UV Spectrophotometric and Colorimetric Method to Quantify Minoxidil in the Development of Trilayer Dissolving Microneedle: Proof of Concept in Ex Vivo and In Vivo Studies in Rats

research Application of validated UV spectrophotometric and colorimetric method to quantify minoxidil in the development of trilayer dissolving microneedle: Proof of concept in ex vivo and in vivo studies in rats

December 2023 in “Annales Pharmaceutiques Françaises”

The UV–Vis Spectrophotometry method effectively measures minoxidil in rat skin for alopecia treatment.

Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

research Minoxidil sulfotransferase enzymatical activity in plants: A novel paradigm in increasing minoxidil response in androgenetic alopecia

August 2023 in “Journal of Cosmetic Dermatology”

Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.

Methylation of CpG Islands in Promoter of Type 2 5-Alpha Reductase and Implications of Finasteride Resistance for BPH Therapy

research 102 Methylation of CpG islands in promoter of type 2 5-α reductase and implications of finasteride resistance for BPH therapy

March 2016 in “European Urology Supplements”

Methylation in specific gene region causes finasteride resistance in some BPH patients.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

research Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice

6 citations , November 2022 in “Journal of Tissue Engineering and Regenerative Medicine”

Zebularine improved skin structure but delayed wound healing in diabetic mice.

research Design, synthesis and anti-tumor evaluation of novel thiohydantoin congeners as androgen receptor antagonists with in vivo study.

May 2024 in “Journal of molecular structure”

A new compound, 3a, effectively fights prostate cancer better than finasteride.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Breaking the ‘rule-of-five’ to access bridged bicyclic heteroaromatic bioisosteres

February 2026 in “Nature Synthesis”

A new method creates unique chemical structures that could improve drug discovery.

research Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

20 citations , June 2022 in “Molecules”

Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.

research Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism

51 citations , September 2008 in “Journal of Investigative Dermatology”

Vitamin D receptor may help protect against UV-induced skin cancer.

Resident T Cell Activation Leads to Human Hair Follicle Immune Privilege Loss Ex Vivo, Which Is Prevented by the DHODH Inhibitor Farudodstat: Relevance for Alopecia Areata

research Resident T cell activation leads to human hair follicle immune privilege loss ex vivo, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata

April 2026 in “Frontiers in Medicine”

Farudodstat may help prevent hair loss in alopecia areata by stopping immune attacks on hair follicles.

Resident T Cell Activation Leads to Human Hair Follicle Immune Privilege Loss Ex Vivo, Prevented by DHODH Inhibitor Farudodstat: Relevance for Alopecia Areata

research Image 1_Resident T cell activation leads to human hair follicle immune privilege loss ex vivo, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata.pdf

April 2026 in “Figshare”

Farudodstat can prevent hair follicle immune damage linked to alopecia areata.

Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

research Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety

7 citations , August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

research Breaking the “rule-of-five” to access Bridged Bicyclic Heteroaromatic Bioisosteres

3 citations , May 2025

A new method creates valuable compounds for drug discovery by breaking traditional chemical rules.

research Synthesis of mimics of steroid A ring as potential enzyme inhibitors

September 2002 in “Research Repository (Kingston University London)”

Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

research Targeting telomeric RNA quadruplexes with natural metabolites to prevent cancer

2 citations , November 2024 in “In Silico Pharmacology”

research Synthesis and anticancer activity of phenylpropanoid sucrose esters

4 citations , January 2011

Phenylpropanoid sucrose esters show potential as anticancer agents.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research DYS459, DYS391, DYS388 and DYS19 genetic loci have high allelic frequency in patients with prostate cancer

August 2015 in “International Journal of Genetics and Molecular Biology”

Certain genetic markers may increase or decrease prostate cancer risk.

research 1424 METHYLATION AND DECREASED EXPRESSION OF 5-ALPHA REDUCTASE 2 IN HUMAN PROSATE SAMPLES: IMPLICATIONS FOR RESISTANCE TO THERAPY FOR BPH

March 2010 in “The Journal of Urology”

Methylation of the 5-AR2 gene may cause resistance to Finasteride in BPH patients.

research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles

September 2025 in “Science Advances”

PADI4 enzyme slows down cell growth in developing hair follicles.

research A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy

188 citations , June 1998 in “Molecular cell”

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

research The Vitamin D Receptor as Tumor Suppressor in Skin

55 citations , January 2020 in “Advances in experimental medicine and biology”

Vitamin D and its receptor may help prevent skin cancer.

research 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway

45 citations , September 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Vitamin D3 and its receptor help protect skin from UVB-related cancer.

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