research Etoposide sensitizes CT26 colorectal adenocarcinoma to radiation therapy in BALB/c mice
Etoposide makes radiation therapy more effective against tumors without major side effects.
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research Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling
Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.
research A fast and simple FIA-chemiluminescence method for the evaluation of Roselle flowers as scavenger of the free radicals generated by UV irradiated antibiotics
Roselle flower extracts can protect against free radical damage in UV-irradiated antibiotics.
research Skin Toxicity in Palliative Radiation Therapy
Radiation therapy for cancer often causes skin problems like redness, dryness, and pain.
research Il-10 family members as novel responders to genotoxic stress
IL-19 and IL-24 help cells respond to DNA damage and could be targeted for cancer and age-related disease treatments.
research Androgenic and anti-androgenic effects of progesterone derivatives with different halogens as substituents at the C-6 position
Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.
research A computer‐aided drug repurposing: the antibacterial agents targeting GroEL
Daprodustat, combined with PAβN, could be a new antibacterial treatment.
research PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands
PRMT5 inhibitors effectively fight adenoid cystic carcinoma in salivary glands.
research Advances in nanomaterial-mediated CRISPR/Cas delivery: from lipid nanoparticles to vesicle-derived systems
Ionizable lipid nanoparticles are the best for delivering gene-editing therapies.
research Diagnosis and treatment of polonium poisoning
Polonium poisoning is diagnosed by detecting it in urine and feces, and treated with supportive care, infection prevention, and chelation therapy.
research SUN-195 Falsely Elevated Testosterone Levels: Role of LC-MS/MS in Reducing Unnecessary Testing
Using LC-MS/MS for hormone measurement can prevent false high testosterone results and avoid unnecessary tests.
research Baiting Proteins with C60
C60 fullerenes can alter protein function and may help develop new disease inhibitors.
research Establishment and characterization of a radiation‐induced dermatitis rat model
Researchers created a rat model to study skin damage caused by radiation, which could help develop new treatments.
research DAB-labelling for collagen type III and PDGFR as control on equine skin sections.
DAB labeling effectively identifies collagen type III and PDGFR in horse skin, but may show false positives.
research Functional Enhancers As Master Regulators of Tissue-Specific Gene Regulation and Cancer Development.
Enhancers and super-enhancers are key in controlling specific gene activity and can play a role in cancer development.
research Androgen antagonists in androgen target tissues
Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.
research In Silico Screening of DrugBank Compounds as Potential Inhibitors for Human Steroid 5α-Reductase 2 for Androgen-Related Diseases
Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.
research The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim
Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.
research Dermal Delivery of Topically Applied Oligonucleotides via Follicular Transport in Mouse Skin
Topical oligonucleotide therapy targets hair follicles effectively.
research Effects of the androgen receptor overexpression in prostate cancer
Androgen receptor overexpression can increase prostate cancer cell growth even without hormones.
research Reverse Protein Engineering Of Firefly Luciferase
The protein's size was reduced, but more work is needed to confirm its function.
research Wnt is back in drugmakers' sights, but is it druggable?
Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.
research A machine learning and network framework to discover new indications for small molecules
The model successfully predicted new uses for existing drugs, like using certain hormonal and heart medications for respiratory and Parkinson's diseases, and a cancer drug for diabetes.
research Converging physiological roles of the anthrax toxin receptors
CMG2 and TEM8 receptors have distinct roles in skin and growth disorders, affecting collagen breakdown and growth.
research Theoretical evaluation of interaction of some dibenzo derivatives on both androgen receptor and 5α-reductase enzyme
Certain Dibenzo derivatives may help treat prostate cancer.
research Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors
Some synthetic carbohydrate receptors, especially compounds 3 and 15, show strong potential for treating Zika virus.
research Immunomodulatory Potential of a Bibenzyl-dihydrophenanthrene Derivative Isolated from Calanthe cardioglossa
Calancardin B may help reduce inflammation in immune cells.
research A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin⋅hydrochloride for thyroid cancer treatment in vitro and in vivo
GC10/DOX hydrogel shows promise as an effective thyroid cancer treatment.
research Advances in structure-based drug design targeting membrane protein markers in prostate cancer
Computational methods help design drugs targeting prostate cancer proteins.
research Pinkie, the First Viable Germline Hypomorph Allele of Retinoid X Receptor Alpha, Reveals an Important Role for RXRa in Th2 Development.
RXRa is crucial for Th2 immune cell development and may link nutrition to immune health.