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Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells

research Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

August 1994 in “Molecular Endocrinology”

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

research Evidence for multiple, developmentally regulated isoforms of Ptprq on hair cells of the inner ear

11 citations , August 2010 in “Developmental neurobiology”

Ptprq has multiple forms that change during inner ear development.

research Drug Repurposing for Rare Diseases

246 citations , February 2021 in “Trends in Pharmacological Sciences”

Drug repurposing offers a faster, cheaper way to find treatments for rare diseases.

research Life Sciences Discovery and Technology Highlights

March 2019 in “SLAS TECHNOLOGY”

New technologies show promise in healing wounds, treating cancer, autoimmune diseases, and genetic disorders.

research Bicalutamide

January 2025

research Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors

17 citations , December 2015 in “Bioorganic & Medicinal Chemistry”

3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.

research Interaction of spironolactone with rat skin androgen receptor

23 citations , July 1979 in “Canadian journal of biochemistry”

Spironolactone reduces the number of androgen receptor sites in rat skin by blocking them with its metabolite.

research Nuclear and cytosol Androgen Receptor in Androgen Dependent Dermatoses in Female Patients

5 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

Nuclear AR levels give better insight into hormone effects in skin conditions.

research Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size

15 citations , May 2009 in “Steroids”

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.

research Real-world assessment of ritlecitinib in patients with severe alopecia areata: a 24-week multicentre retrospective study

3 citations , July 2025 in “Clinical and Experimental Dermatology”

Ritlecitinib may be more effective for severe alopecia areata than conventional treatments.

research Bone Regeneration Is Regulated by Wnt Signaling

220 citations , August 2007 in “Journal of Bone and Mineral Research”

Wnt signaling is crucial for bone regeneration.

research Abstract A12: Androgen receptor inhibition is involved in Finasteride-reduced AML cell proliferation

May 2023 in “Blood cancer discovery”

Finasteride reduces AML cell growth by inhibiting androgen receptors.

research Development of a new gas chromatography–mass spectrometry (GC–MS) methodology for the evaluation of 5α-reductase activity

17 citations , January 2013 in “Talanta”

A new method was developed to accurately measure enzyme activity related to prostate health.

research Treatment-resistant giant unilateral Bowen’s disease of the scalp responding to radiotherapy

8 citations , December 2008 in “Clinical and Experimental Dermatology”

Radiotherapy was effective for treating a large scalp plaque of Bowen's disease when other treatments failed.

research PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells

2 citations , July 2024 in “Bioengineering”

PRF lysates reduce inflammation in cancer cells and boost immune response in healthy oral cells.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Does Active Form of Vitamin D3 Prevent Hair Follicles from Radiation Toxicity?

research 635 poster Does active form of vitamin D3 prevent hair follicules from radiation toxicity?

October 2004 in “Radiotherapy and oncology”

Active vitamin D3 might protect hair follicles from radiation damage.

research Latent transforming growth factor beta-binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease. From molecular mechanisms to clinical translation prospects

March 2026 in “Folia Histochemica et Cytobiologica”

LTBP1 is a key regulator in diseases and a potential target for new treatments.

research A novel actor in skin biology: the mineralocorticoid receptor

7 citations , October 2015 in “Experimental dermatology”

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.

Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1<i>H</i>-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

37 citations , September 2003 in “Journal of Medicinal Chemistry”

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Novel Synthesis of Nicotinamide Derivatives with Cytotoxic Properties

research Novel synthesis of nicotinamide derivatives of cytotoxic properties

51 citations , March 2006 in “Bioorganic & Medicinal Chemistry”

Newly made nicotinamide compounds could potentially treat cancer.

Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro

research Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro

37 citations , March 2010 in “British Journal of Dermatology”

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.