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Ruxolitinib Reverses Alopecia Areata Via a Triple Mechanism: JAK-STAT Inhibition, Localized Oxidative Stress Attenuation and Selective Apoptosis Modulation

research Ruxolitinib reverses alopecia areata via a triple mechanism: JAK-STAT inhibition, localized oxidative stress attenuation and selective apoptosis modulation

March 2026 in “Journal of Translational Autoimmunity”

Ruxolitinib helps regrow hair in alopecia areata by blocking inflammation, reducing stress, and controlling cell death.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research Ginecomastia por finasteride

1 citations , November 2006 in “Medicina de Familia SEMERGEN”

research [A patient with advanced recurrent breast cancer who firmly resisted hair loss and was then treated by combination therapy with high-dose toremifene and capecitabine].

March 2007

The combination of high-dose toremifene and capecitabine was effective for advanced recurrent breast cancer.

research Ritlecitinib: Efficacy of a Novel Therapy for Severe Alopecia Areata in Patients Aged 12 Years and Older

December 2025 in “Actas Dermo-Sifiliográficas”

Ritlecitinib is effective and safe for treating severe alopecia areata in people aged 12 and older.

research Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis

8 citations , July 2024 in “Journal of Advanced Research”

CDK inhibitors may help treat ARDS and psoriasis but need more testing for safety and effectiveness.

research Effects of androgen deprivation on chronic bacterial prostatitis in a rat model

38 citations , August 2003 in “International Journal of Urology”

Finasteride and levofloxacin effectively reduce chronic bacterial prostatitis severity.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

research Antiandrogenic activity of Riboflavin 5′-phosphate (FMN) in 22Rv1 and LNCaP human prostate cancer cell lines

1 citations , January 2022 in “European Journal of Pharmacology”

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

research Five-alpha-reductase Inhibitors for prostate cancer prevention.

37 citations , April 2008 in “The Cochrane library”

5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.

Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

research Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition

98 citations , April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

research Testosterone Reduces Knee Passive Range of Motion and Expression of Relaxin Receptor Isoforms via 5α-Dihydrotestosterone and Androgen Receptor Binding

23 citations , March 2014 in “International Journal of Molecular Sciences”

Testosterone reduces knee flexibility by affecting relaxin receptors.

The Dose-Response of Percutaneous Estradiol Implants on the Skeletons of Postmenopausal Women

research The dose‐response of percutaneous oestradiol implants on the skeletons of postmenopausal women

June 1995 in “International Journal of Gynecology & Obstetrics”

Higher doses of oestradiol implants improve bone density in postmenopausal women.

Complex Extract of Polygonatum Sibiricum and Nelumbinis Semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

research Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

May 2023 in “Nutrients”

A mix of Polygonatum sibiricum and Nelumbinis semen may ease menopause symptoms with fewer side effects.

Proxalutamide Reduces Hospitalization Rate in Mild-to-Moderate COVID-19 Female Patients: A Randomized Double-Blinded Placebo-Controlled Trial

research Proxalutamide (GT0918) Reduces the Rate of Hospitalization in mild-to-moderate COVID-19 Female Patients: A Randomized Double-Blinded Placebo-Controlled Two-Arm Parallel Trial

5 citations , July 2021 in “medRxiv (Cold Spring Harbor Laboratory)”

Proxalutamide significantly lowered hospitalization rates in women with mild-to-moderate COVID-19.

Comparative Efficacy and Safety of JAK Inhibitors in the Treatment of Moderate-to-Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis

research Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis

April 2024 in “Frontiers in pharmacology”

Brepocitinib 30mg is most effective for moderate-to-severe alopecia areata, but ritlecitinib 50mg may offer a better balance of safety and effectiveness.