research Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats
Mutations in the DSG4 gene cause fragile, sparse hair in humans, mice, and rats.
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research Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase
Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.
research 52243 AH-001: An Emerging Androgen Receptor Degrader Showing Therapeutic Potential in Addressing Androgenetic Alopecia (AGA)
AH-001 could be a safer and more effective treatment for hair loss.
research Editors' Picks
Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.
research The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-kb Genomic DNA Containing Five Basic Keratin Genes
Hirosaki hairless rats lack hair due to missing DNA with key keratin genes.
research Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments
Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.
research EFECTO DEL FINASTERIDE EN UN MODELO DE ISQUEMIA/REPERFUSION EN CORAZON DE RATA
Finasteride may reduce heart damage in rats.
research Production of ultraviolet-light-induced skin erythema in the hairless rat: a comparison with the haired rat in screening for anti-inflammatory drugs
Hairless rats are good for testing anti-inflammatory drugs, similar to haired rats, without needing to remove fur.
research The Influence of Portocaval Shunting on Inner Ear Structures
PCS rats show significant inner ear damage and zinc deficiency, similar to liver cirrhosis patients.
research Comparison of Alopecia areata in Human and Nonhuman Mammalian Species
The document concludes that certain rats and mice are useful for studying hair loss in humans and testing treatments.
research Study on treatment of Pterocarpus indcus Willd extracts on rat androgenetic alopecia
Pterocarpus indcus Willd extracts taken orally can reduce hair loss in rats.
research Male Accessory Sex Glands
Male accessory sex glands in rats rarely develop tumors and respond to hormones.
research The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene
A gene mutation causes lanceolate hair in rats by disrupting hair shaft integrity.
research Intragenic deletion in the Desmoglein 4 gene underlies the skin phenotype in the Iffa Credo “hairless” rat
A gene deletion causes the "hairless" trait in Iffa Credo rats.
research Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor
CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.
research Imaging prostate cancer (PCa) with [99m Tc(CO)3 ]finasteride dithiocarbamate
A new compound was effective for imaging prostate cancer in rats.
research Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat
Finasteride reduces pain in male rats and works better with testosterone.
research Neurosteroid-sensitive δ-GABAAreceptors: A role in epileptogenesis?
Blocking neurosteroid production can lead to more seizures and faster epilepsy onset in rats.
research Synthesis and bioactivity of new Finasteride conjugate
New Finasteride conjugate improves prostate treatment and vital signs in rats.
research Đánh giá tác dụng kích thích mọc tóc của cao chiết cỏ nhọ nồi trên động vật thực nghiệm
Eclipta prostrata extract significantly promotes hair growth in rats.
research Rapid preparation of a noncultured skin cell suspension that promotes wound healing
Researchers developed a new method to quickly prepare skin cells that improve wound healing in rats.
research EFEKTIVITAS EKSTRAK ETANOL DAN EKSTRAK KLOROFORM SIPUT ONCHIDID (Onchidium thyphae) SEBAGAI PENUMBUH RAMBUT PADA TIKUS (Rattus norvegicus)
Chloroform extract from onchidiid snail promotes hair growth in rats.
research Evaluation of wavelength-dependent hair growth effects on low-level laser therapy: an experimental animal study
The 830-nm wavelength was most effective at promoting hair growth in rats using low-level laser therapy.
research Evaluation of Acute and Repeated Dose Toxicity of the Polyherbal Formulation Linkus Syrup in Experimental Animals
Linkus cough syrup is effective and safe with no side effects or toxicity in rats.
research Neuropharmacological profile of Eclipta alba (Linn.) Hassk
Eclipta alba extract improved learning, memory, and stress-related ulcers in rats without affecting movement or causing anxiety.
research Minoxidil and Dexamethasone Eluting Nanofiber Dressing for Cutaneous Wound Healing in Rat
The new wound dressing with minoxidil and dexamethasone could speed up healing and reduce scarring in rats.
research Topical Transplantation of Bone Marrow Mesenchymal Stem Cells Made Deeper Skin Wounds Regeneration
Bone marrow stem cells improve healing of deep skin wounds.
research STRESS AND AGING*
Anabolic steroids may help prevent aging effects by reducing toxicity, not by their usual functions.
research Investigation of the effects of dexpanthenol on brain tissue in experimental global cerebral ischaemia-reperfusion injury
Dexpanthenol helps protect the brain and improve motor skills after a stroke.
research Progesterone-induced spike-wave discharges are inhibited by finasteride
Finasteride blocks progesterone's effect on brain activity linked to epilepsy.