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GlossaryReceptor Activator of Nuclear Factor Kappa-Β Ligand

protein that promotes bone resorption by activating osteoclasts

Receptor Activator of Nuclear Factor Kappa-Β Ligand (RANKL) is a protein that plays a crucial role in bone metabolism by promoting the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. It is also involved in immune system regulation and has been linked to conditions such as osteoporosis and rheumatoid arthritis.

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Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

research Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity

26 citations , May 2012 in “Cellular and Molecular Life Sciences”

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

91 citations , May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation

97 citations , June 2013 in “Journal of Dermatological Science”

Understanding EGFR's role in skin is crucial for better treatments and managing side effects.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ

11 citations , July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit

research Receptor activator of NF-κB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit

60 citations , March 2011 in “Proceedings of the National Academy of Sciences of the United States of America”

RANK-RANKL signaling is essential for hair growth and skin health.

research The role of nuclear hormone receptors in cutaneous wound repair

68 citations , December 2014 in “Cell Biochemistry and Function”

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

research In Vitroandin VivoStructure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring

20 citations , September 2005 in “Endocrinology”

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Stress-Induced c-Jun-Dependent Vitamin D Receptor Activation Dissects the Non-Classical VDR Pathway from the Classical VDR Activity

research Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity

31 citations , January 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

research Dynamic Signals for Hair Follicle Development and Regeneration

60 citations , July 2011 in “Stem Cells and Development”

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

research Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

research Molecular genetics of androgen insensitivity

January 1995 in “Adolescent and pediatric gynecology”

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

207 citations , March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Role of insulin resistance and diet in acne

39 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

research Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

21 citations , November 2022 in “Frontiers in immunology”

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

research Cicatricial alopecia: What’s new in etiology?

November 2015 in “European Journal of Inflammation”

Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.

A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

research A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

1 citations , November 2023 in “iScience”

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

research Beyond Wavy Hairs

160 citations , June 2008 in “American Journal Of Pathology”

EGFR signaling is crucial for skin and hair health, and targeting it could help treat skin diseases and cancer.

research Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation

29 citations , December 2016 in “The EMBO Journal”

Gata6 is important for protecting hair growth cells from DNA damage and keeping normal hair growth.

research Role of vitamin D and calcium signaling in epidermal wound healing

15 citations , August 2022 in “Journal of endocrinological investigation”

Vitamin D and calcium are important for quick and effective skin wound healing.

research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia

25 citations , August 2014 in “Endocrinology”

Researchers created a mouse model of a type of rickets that does not cause hair loss.

research The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia

February 2024 in “International Journal of Molecular Sciences”

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

research Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation

79 citations , August 1998 in “The Journal of Cell Biology”

Keratin 16 delays skin maturation and affects skin and hair development in mice.

research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17

32 citations , February 2024 in “The Journal of Experimental Medicine”

CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.

research Role of the Wnt signaling pathway in keratoacanthoma

2 citations , November 2019 in “Cancer reports”

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

research Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?

60 citations , May 2015 in “Archives of dermatological research”

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Peroxisome Proliferator Activated Receptors Gamma Serum Levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case-Control Study

research Peroxisome Proliferator Activated Receptors Gamma Serum levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case Control Study

July 2022 in “Research Square (Research Square)”

Lower PPARγ levels and specific gene variations are linked to more severe Frontal Fibrosing Alopecia.