research PROTACs in 2025: from the laboratory concept to clinical breakthrough
PROTACs have become a breakthrough in medicine by effectively targeting and degrading specific proteins to treat diseases.
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900-930 / 1000+ resultsresearch Evolving CRBN ligands enhance the drug-like properties of protein degraders
Improved CRBN ligands make protein degraders more effective and drug-like.
research Tebentafusp-tebn (Kimmtra®)
Tebentafusp-tebn improves survival rates in uveal melanoma patients but has common side effects like rash and fatigue.
research Comparison of Efficacy and Specificity in Cancer‐Targeting Prodrug Conjugates
The document concludes that biotin, folate, and RGD peptides are promising for targeting cancer cells with prodrugs, but the conjugates are not yet tested for use.
research PLATELET RICH FIBRIN- A Natural Regenerative Biomaterial
Platelet Rich Fibrin (PRF) is a safe, effective tool for tissue regeneration and healing in various medical fields.
research Synthesis and biological activity of raltitrexed-carrier conjugates.
Raltitrexed conjugates are less potent than the free drug but more effective at high concentrations.
research Enriched-GF: A Reproducible High-Yield Autologous Blood-Derived Growth Factor Method for Regenerative Medicine
The Enriched-GF method efficiently produces high-yield growth factors for tissue repair.
research PLATELET-RICH PLASMA AND PLATELET FIBRIN: STANDARDIZED PREPARATION PROTOCOLS, MECHANISMS OF ACTIVATION, STORAGE STABILITY, AND REGULATORY FRAMEWORKS
Standardized protocols are crucial for effective use of platelet-rich plasma and fibrin in tissue regeneration.
research Screening of Sheep Fibroblast Cell Line with the Spider Dragline Silk Protein Gene
Sheep cells were successfully modified to include a spider silk protein gene.
research Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine
The new vaccine platform led to a stronger immune response and better protection against the flu than the traditional vaccine.
research Injectable Polypeptide‐Protein Hydrogels for Promoting Infected Wound Healing
The hydrogel promotes faster healing of infected wounds by enhancing tissue regeneration and preventing infection.
research Platelet-Rich Fibrin Matrix
Platelet-rich fibrin matrix improves tissue regeneration better than platelet-rich plasma.
research Ανάπτυξη καινοτόμων πεπτιδικών φορέων με ιδιότητες αυτοσυναρμογής για τοπική χορήγηση φαρμάκων
Self-assembling peptide hydrogels effectively deliver drugs locally, enhancing treatment and reducing side effects.
research Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications
RADA16 is a promising material for tissue repair and regenerative medicine but needs improvement in strength and cost.
research Provenge is Talk of GU Malignancies Congress
Provenge extends prostate cancer survival by about 4 months.
research Preparation of highly-concentrated autologous platelet-rich plasma for biomedical use
A simple method was developed to prepare concentrated platelet-rich plasma for use in healing and tissue repair.
research Single-Administration Long-Acting Microarray Patch with Ultrahigh Loading Capacity and Multiple Releases of Thermally Stable Antibodies
A new patch can deliver stable antibodies over time for potential HIV treatment.
research Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine
A new vaccine using a porous scaffold boosts immunity and protects against the flu better than traditional methods.
research Platelet-Rich Fibrin
Platelet-rich fibrin helps in healing and rejuvenation but results vary and can take time.
research Structure-guided PEGylated fibroblast growth factor 2 variants accelerate wound healing with improved stability
Compound 6 is a promising candidate for better wound healing.
research Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis
A new engineered treatment shows promise in curing heart fibrosis.
research Platelet-Rich Plasma and its Derivatives for Tissue Engineering
Platelet-rich plasma helps heal wounds and regenerate tissue in various medical fields.
research Platelet Concentrates in Regenerative Medicine: A Comparative Review of Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factors
PRF and CGF are becoming more popular than PRP in regenerative medicine due to their simplicity and lack of additives.
research Biotherapeutic Applications of Platelet-Rich Plasma in Regenerative Medicine
research Applications and Implications of Heparin and Protamine in Tissue Engineering and Regenerative Medicine
Heparin and protamine are promising in tissue repair and organ regeneration, including skin and hair.
research Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs
Platelet-rich fibrin shows promise in healing cartilage and joint injuries but needs more testing.
research Sacituzumab tirumotecan (sac-TMT/MK-2870/SKB264): a novel antibody–drug conjugate in breast cancer
Sacituzumab tirumotecan shows promise in treating breast cancer with manageable side effects.
research Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist
The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.
research PC-SPES Studies Promising, But Manufacturer Shuts Down
Promising cancer treatments were found, but the manufacturer closed.
research PLATELET CONCENTRATE AND TISSUE REGENERATION: DOES IT WORK? A PRE-CLINICAL STUDY
Platelet concentrates may help tissue regeneration and have potential for regenerative therapies.