January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
March 2006 in “The FASEB Journal” Two methods improved nerve regeneration and touch recovery in skin grafts for burn patients.
March 2023 in “Advances in Cosmetic Surgery” Exosomes, tiny cell-released particles, may help hair growth, but their exact role is unclear, they're not FDA-approved, and their unregulated use can cause side effects.
521 citations
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January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
425 citations
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June 2020 in “Nature” Scientists created human skin with hair from stem cells, which could help treat hair loss and skin conditions.
408 citations
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January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
202 citations
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August 2007 in “Biomaterials” Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.
201 citations
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April 2017 in “Regeneration” Macrophages and fibroblasts help repair organs after injury, affecting whether they regenerate or scar.
188 citations
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March 2018 in “Frontiers in Immunology” Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.
176 citations
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June 2019 in “Cells” Different fibroblasts play key roles in skin healing and scarring.
162 citations
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July 2011 in “Biomacromolecules” Chitosan nanofiber scaffolds improve skin healing and are promising for wound treatment.
133 citations
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September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
75 citations
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March 2014 in “Journal of Investigative Dermatology” Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
71 citations
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February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
71 citations
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January 2020 in “Stem Cells International” Epidermal stem cells help heal skin, but how they work is still unclear.
57 citations
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May 2007 in “Nature” Adult mice can grow new hair from skin wounds.
42 citations
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January 2014 in “Cold Spring Harbor Perspectives in Medicine” Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.
28 citations
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October 2024 in “Advanced Materials” Artificial skin can heal wounds without scars and regenerate hair, oil, and sweat glands.
28 citations
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February 2016 in “F1000Research” Understanding glycans and enzymes that alter them is key to controlling hair growth.
25 citations
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April 2008 in “Archives of Dermatological Research” Encapsulated human hair cells can substitute for natural hair cells to grow hair.
23 citations
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December 2001 in “Lasers in Surgery and Medicine” Permanent hair removal is hard, but using longer laser pulses at lower power might improve results.
15 citations
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January 2019 in “Experimental Dermatology” Lanyu pigs show that partial-thickness wounds can partially regenerate important skin structures, which may help improve human skin healing.
13 citations
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September 2017 in “Journal of Dermatological Science” Hydrogen peroxide in hair dye can cause hair loss.
12 citations
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April 2019 in “Nature protocols” Scientists created a functional 3D skin system from stem cells that can be transplanted into wounds.
11 citations
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November 2015 in “Experimental Dermatology” The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.
11 citations
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November 2009 in “Brazilian Journal of Medical and Biological Research” Young C57BL/6 mice heal better than BALB/c mice, and older mice heal faster but regenerate worse.
8 citations
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March 2019 in “Open Biology” The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.
7 citations
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June 2020 in “npj regenerative medicine” GDNF helps grow hair and heal skin wounds by acting on hair stem cells.
2 citations
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September 2025 in “Food Science and Biotechnology” Placenderm® can improve hair health and promote hair regrowth.
1 citations
,
August 2023 in “Genome research” The spiny mouse regenerates ear tissue asymmetrically, with gene expression differences possibly explaining its unique healing abilities.