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research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata

4 citations , July 2024 in “Pharmacology Research & Perspectives”

Ritlecitinib is safe and may effectively treat alopecia areata.

research 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1)

5 citations , April 2019 in “Journal of Investigative Dermatology”

Oral JAK inhibitors improved alopecia areata by modulating immune responses and boosting hair growth.

research 650 Controlling mTORC1 activity as a novel therapeutic strategy for managing human hair growth and pigmentation

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking mTORC1 activity with rapamycin could help increase hair pigmentation and growth, potentially reversing gray hair.

research Association of prior 5-α-reductase inhibitor exposure with ICI benefit in metastatic RCC: Multicentre cohort with single-cell immune profiling.

March 2026 in “Journal of Clinical Oncology”

Using 5-α-reductase inhibitors before treatment improves outcomes for patients with metastatic renal cell carcinoma.

High-Performance Liquid Chromatographic Determination of the Enantiomers of the Benzoquinolinone LY 191704, a Human Type 1 5α-Reductase Inhibitor, in Plasma

research High-performance liquid chromatographic determination of the enantiomers of the benzoquinolinone LY 191704, a human type 1 5α-reductase inhibitor, in plasma

1 citations , March 1997 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Researchers developed a method to measure different forms of a drug that could help treat prostate issues and hair loss, and found how these forms behave in animals.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

18 citations , October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

research Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy

September 2025 in “Journal of Medicinal Chemistry”

AR-27 E-Chol siRNA can effectively regrow hair by reducing androgen receptor gene activity.

Significant Improvement With Ivarmacitinib After Suboptimal Response to Tofacitinib in Severe Alopecia Areata: A Case Report and Literature Review

research Significant improvement with ivarmacitinib after suboptimal response to tofacitinib in severe alopecia areata: a case report and literature review

February 2026 in “Frontiers in Immunology”

Ivarmacitinib significantly improved hair regrowth in severe alopecia areata after tofacitinib was less effective.

research Pharmacophore and Atom Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors

2 citations , November 2018 in “Indian Journal of Pharmaceutical Education”

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

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