1 citations
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August 2020 Croton membranaceus root extract can change how drugs are processed in the body.
15 citations
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May 1987 in “Fundamental and applied toxicology” SMR-2 and SMR-6 are much more toxic than retinoic acid, causing severe side effects.
42 citations
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January 2002 in “Skin Pharmacology and Physiology” Reconstructed skin models are useful for studying how skin processes certain chemicals.
5 citations
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January 1994 in “PubMed” February 2026 in “UiTM Institutional Repositories (Universiti Teknologi MARA)” This study investigates the metabolic pathway of cis-urocanic acid (cis-UCA) upon UVB exposure, using NMR spectroscopy, molecular docking, and cell viability assays with human keratinocytes (HaCaT). The research reveals that cis-UCA can react with reactive sulphur species (RSS) donors without the involvement of the glutathione-S-transferase (GST) enzyme, leading to the formation of a new compound, 4-imidazoleacrylic acid-3-thiol. The study also finds that the formation of glutathione and cysteine conjugates can occur non-enzymatically, challenging the previously proposed GST-dependent pathway. Molecular docking shows that the glutathione conjugate has a higher binding affinity with GST than sulforaphane, suggesting a regulatory role. In vitro studies demonstrate that UVB exposure with cis-UCA reduces cell viability, but the presence of sulphide donors mitigates this toxicity, highlighting their protective role. This research provides new insights into cis-UCA metabolism and suggests an alternative RSS-driven pathway, impacting our understanding of UCA's role in UVB-induced skin reactions.
October 2006 in “Clinical Cancer Research” Antioxidants can block the cancer-fighting effects of doxorubicin.
January 1987 in “Toxicological sciences” SMR-2 and SMR-6 are much more toxic than retinoic acid, causing severe symptoms and organ damage in mice.
5 citations
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May 2020 in “Clinical Phytoscience” Cuscuta reflexa leaves extract may help lower blood sugar and improve diabetes symptoms.
1 citations
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December 2015 in “Parkinsonism & Related Disorders” The anti-hangover product may boost enzyme activity to help prevent brain damage.
2 citations
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January 1997 in “Principles of Medical Biology” Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.
June 1998 in “Pathophysiology” Selenium is crucial for health, but both deficiency and excess can cause problems.
18 citations
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July 2009 in “Drug Metabolism and Disposition” Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” Anti-glycation treatments might slow skin aging, but more research is needed.
30 citations
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December 2019 in “PLoS ONE” The new delivery system improved raloxifene's skin absorption and effectiveness against cancer cells.
October 2018 in “Exercise Biochemistry Review” Aerobic exercise helps protect the intestines by improving their barrier function.
17 citations
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January 2012 in “IOSR Journal of Environmental Science Toxicology and Food Technology” High doses of Tridax procumbens extract can be toxic, affecting liver and kidneys.
1 citations
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September 2023 Tridax procumbens and ginger juice together protect the liver from paracetamol damage.
36 citations
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June 2019 in “eLife” The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.
75 citations
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March 2007 in “Journal of Biological Chemistry” QSOX enzymes help form protein bonds in cells, especially in tissues with high secretory activity.
June 2023 in “SDÜ Tıp Fakültesi Dergisi” Rutin may protect against stomach damage caused by sodium valproate.
4 citations
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November 2018 in “Journal of Pharmaceutical and Biomedical Analysis” Roselle flower extracts can protect against free radical damage in UV-irradiated antibiotics.
48 citations
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February 2025 in “Nano-Micro Letters” Microneedles offer a promising, painless way to treat skin diseases but need improvements for better use.
35 citations
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January 2013 in “The Journal of experimental medicine/The journal of experimental medicine” CD98hc's role in skin health decreases with age.
32 citations
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December 2004 in “BMC Public Health” Men can report their own balding patterns well enough for large health studies.
19 citations
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November 2023 in “npj Regenerative Medicine” Synthetic melanin applied to skin speeds up wound healing.
2 citations
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January 2018 in “Elsevier eBooks” Targeted therapies for lung cancer are effective but require careful management of side effects to benefit patients.
September 2025 in “Journal of Health Sciences” A hair tonic with cumaru extract may help improve scalp psoriasis naturally.
February 2025 in “Intisari Sains Medis” PDRN from salmon may slow skin aging by improving skin quality and reducing inflammation.
January 2025 in “Scripta Medica” PDO, PLLA, and PCL threads increase collagen in ageing skin but don't change MMP1 gene expression.
April 2018 in “Journal of Investigative Dermatology” Resveratrol activates the Nrf2 pathway in human skin, significantly increasing the production and distribution of the antioxidant glutathione.