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GlossaryRPMI-1640

nutrient-rich liquid used to grow cells in labs

RPMI-1640 is a type of nutrient-rich liquid used to grow cells in a laboratory. It provides essential vitamins, amino acids, and other nutrients that cells need to survive and multiply, making it a common choice for culturing human and animal cells in research, including studies on hair growth and alopecia.

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research Cultivation of Hair Matrix Cells from Cashmere Goat Skins and Exemplified Applications

3 citations , August 2020 in “Animals”

Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.

research Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma

5 citations , June 2022 in “Journal of Oncology”

Blocking the Hedgehog pathway may help overcome drug resistance in multiple myeloma.

research Direct Effects of Minoxidil on Epidermal Cells in Culture

63 citations , January 1984 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

research Enhancement of In Vitro Hair Shaft Elongation in Follicles Stored in Buffers That Prevent Follicle Cell Apoptosis

10 citations , January 2004 in “Dermatologic Surgery”

Storing hair follicles in special buffers with added protective substances can increase hair growth and reduce cell death.

Antisense Oligonucleotide Targeting Fibroblast Growth Factor Receptor-1 Stimulates Cellular Activity of Hair Follicles in an In Vitro Organ Culture System

research Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in anin vitroorgan culture system

7 citations , March 2007 in “International Journal of Dermatology”

Targeting FGFR-1 with antisense oligonucleotides may help treat baldness by increasing hair follicle activity.

research SUSPECTED CUTANEOUS DRUG TOXICITY IN RHEUMATOID ARTHRITIS—AN EVALUATION

7 citations , January 1993 in “Rheumatology”

Most skin rashes in rheumatoid arthritis patients were not caused by their medication, and careful evaluation allowed most to keep taking their beneficial treatment.

research Isolation and Cultivation of Skin-Derived Precursors

3 citations , January 2018 in “Methods in molecular biology”

The document concludes that skin-derived precursors can be grown and may help in hair growth and skin repair.

research Enhancement of In Vitro Hair Shaft Elongation in Follicles Stored in Buffers That Prevent Follicle Cell Apoptosis

January 2004 in “Dermatologic Surgery”

Storing hair follicles in a special buffer with certain inhibitors can increase hair growth and improve transplant results.

Phytochemical and Nanoparticle-Based Therapeutic Potential of Sphaeranthus Indicus Against Hepatocellular Carcinoma via Cryptomeridiol Targeting

research Phytochemical and nanoparticle-based therapeutic potential of Sphaeranthus indicus against hepatocellular carcinoma via cryptomeridiol targeting

November 2025 in “Frontiers in Oncology”

Sphaeranthus indicus and silver nanoparticles can help treat liver cancer by killing cancer cells.

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations , June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

research Regulation of somatic cell reprogramming through inducible mir-302 expression

308 citations , September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

research Serotoninergic and melatoninergic systems are fully expressed in human skin

249 citations , April 2002 in “The FASEB journal”

Human skin can make serotonin and melatonin.

research Recent advances on the mechanisms of kidney stone formation (Review)

235 citations , June 2021 in “International Journal of Molecular Medicine”

Kidney stones form due to factors like urine concentration, calcium deposits, hormones, gut bacteria, and immune response.

research Mechanical stretch induces hair regeneration through the alternative activation of macrophages

163 citations , April 2019 in “Nature Communications”

Mechanical stretching of the skin can promote hair growth by activating certain immune cells.

research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

139 citations , December 2020 in “Cell Stem Cell”

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations , August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

124 citations , June 2020 in “Cell Stem Cell”

Fat cells in the skin help start healing and form important repair cells after injury.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations , November 2012 in “Stem cells”

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations , September 2005 in “Journal of Investigative Dermatology”

Applying a special compound can promote hair growth without harmful side effects.

research 4D polycarbonates via stereolithography as scaffolds for soft tissue repair

101 citations , July 2021 in “Nature Communications”

4D polycarbonate scaffolds show promise for soft tissue repair due to their biocompatibility, shape memory, and minimal immune response.

Identification of a Link Between Wnt/β-Catenin Signaling and the Cell Fusion Pathway

research Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway

101 citations , November 2011 in “Nature Communications”

Wnt/β-catenin signaling is crucial for cell fusion in placental development.

A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

91 citations , May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Anti-Aging Effect of a Lactococcal Strain: Analysis Using Senescence-Accelerated Mice

research Anti-ageing effect of a lactococcal strain: analysis using senescence-accelerated mice

87 citations , July 2007 in “British Journal Of Nutrition”

Lactococcus lactis strain H61 may reduce some ageing symptoms.

research Characterization of the serotoninergic system in the C57BL/6 mouse skin

84 citations , July 2003 in “European journal of biochemistry”

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

research Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles

78 citations , August 2002 in “Experimental Dermatology”

Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.

The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations , January 2003 in “American Journal of Pathology”

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

The Silver Locus Product (Silv/gp100/Pmel17) as a New Tool for the Analysis of Melanosome Transfer in Human Melanocyte–Keratinocyte Co-Culture

research The silver locus product (Silv/gp100/Pmel17) as a new tool for the analysis of melanosome transfer in human melanocyte–keratinocyte co‐culture

68 citations , March 2008 in “Experimental dermatology”

The new assay can track and measure melanosome transfer between skin cells, confirming filopodia's role in this process.

research Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

66 citations , May 2021 in “Science Advances”

Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.

research Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors

66 citations , December 2014 in “Nature Communications”

Fibroblasts can be turned into melanocytes for potential skin treatments.