January 2022 in “European Proceedings of Life Sciences” Understanding genetic traits can help doctors create personalized detox and nutrition plans to boost antioxidant protection.
835 citations
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October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
416 citations
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September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
171 citations
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July 2007 in “Journal of Investigative Dermatology” A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
121 citations
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March 1989 in “Journal of Investigative Dermatology” Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.
116 citations
,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
106 citations
,
October 2016 in “Cell Stem Cell” PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
105 citations
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May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Activating TRPV3 stops human hair growth.
88 citations
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February 2011 in “Journal of Dermatological Science” Minoxidil helps hair growth by activating the β-catenin pathway.
86 citations
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March 2018 in “ACS Biomaterials Science & Engineering” MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.
77 citations
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July 2020 in “Cell” Muscles and nerves that cause goosebumps also help control hair growth.
69 citations
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September 2006 in “Human Reproduction” Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.
62 citations
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November 2009 in “Aging Cell” Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.
59 citations
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September 2007 in “Biochemical and Biophysical Research Communications” The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.
58 citations
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March 2013 in “Human Reproduction Update” Products should be called 'sperm-safe' only after thorough, well-designed tests.
56 citations
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September 2013 in “Journal of Biochemistry and Molecular Biology” Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.
53 citations
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June 1993 in “Proceedings of the National Academy of Sciences of the United States of America” LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
46 citations
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April 2008 in “Archives of Dermatological Research” Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.
39 citations
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March 2009 in “Clinics in plastic surgery” Injection lipolysis effectively reduces small fat deposits and should be done with care and proper patient selection.
39 citations
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July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
39 citations
,
August 2016 in “Journal of Dermatological Treatment” Stem cell therapy may help treat tough hair loss cases.
37 citations
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April 2017 in “npj Regenerative Medicine” PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.
37 citations
,
March 2012 in “International Journal of Radiation Biology” Mobile phone radiation can cause DNA damage in human hair root cells.
34 citations
,
January 2012 in “Journal of Dermatological Science” Hydrogen peroxide and monoethanolamine in hair dye can cause dermatitis and hair loss.
33 citations
,
September 2012 in “Wound Repair and Regeneration” Applying calreticulin can speed up wound healing in diabetics.
32 citations
,
December 2009 in “Archives of Dermatological Research” Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.
31 citations
,
July 2004 in “Molecular Medicine” Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.
30 citations
,
April 2018 in “Experimental Dermatology” The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.
29 citations
,
July 2014 in “PLoS ONE” Inactivating β-catenin is essential for chick retina regeneration.
29 citations
,
March 2010 in “Journal of Dermatological Science” Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.