99 citations
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January 2002 in “Plastic & Reconstructive Surgery” Fetal rat wounds heal without scars at 16.5 days gestation.
September 2019 in “Encyclopedia of Life Sciences” Wound healing involves complex signaling that stops bleeding, reduces damage, and repairs skin, sometimes without scarring.
4 citations
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January 2025 in “Annals of the New York Academy of Sciences” Spiny mice can regenerate tissues instead of forming scars.
Wound healing involves three phases and various cells and factors, with scars typically forming in adults. Chronic wounds can occur due to various issues, and abnormal scarring can lead to hypertrophic or keloid scars. Emerging research areas include the role of proteins, microRNAs, macrophage manipulation, and stem cell treatment.
733 citations
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September 2009 in “Journal of Cell Science” Wound healing is a complex, multi-phase process involving various cells and activities to repair skin damage.
29 citations
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September 2012 in “Birth Defects Research” Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.
21 citations
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July 2018 in “International Journal of Molecular Sciences” Foxn1 is crucial for skin development and healing, and altering its expression may aid regenerative medicine.
1 citations
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April 2023 in “Science Advances” High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.
13 citations
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February 2017 in “Science” Turning scar-forming cells into fat cells can reduce scarring.
September 2019 in “Romanian Journal of Pediatrics” Fetal skin can heal without scars, offering insights for better wound treatments.
October 2025 in “Clinical Cosmetic and Investigational Dermatology” Targeting specific cell interactions may help treat skin fibrosis.
8 citations
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May 2021 in “Applied Materials Today” New nano composite helps reduce scars and regrow hair during burn wound healing.
9 citations
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November 2018 in “Drug Discovery Today” Using skin stem cells and certain molecules might lead to scar-free skin healing.
471 citations
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October 2012 in “Cellular and Molecular Life Sciences” Understanding developmental pathways can improve wound healing treatments.
66 citations
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July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
102 citations
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April 2014 in “PloS one” Wharton’s Jelly stem cells from the umbilical cord improve skin healing and hair growth without scarring.
11 citations
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July 2021 in “Nanomaterials” Wound covers with α-13'-COOH from vitamin E can improve and speed up wound healing.
8 citations
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July 2024 in “Scientific Reports” Salicylate helps wounds heal without scarring in mice.
August 2022 in “Research Square (Research Square)” Implanted special stem cells from hair follicles helped heal wounds faster and with less scarring in mice.
145 citations
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November 2018 in “Nature Communications” The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
February 2026 in “Exploration” Advancements in gene therapy, stem cells, and biomaterials show promise for reducing scarring in wound healing, but face clinical challenges.
October 1982 in “American Journal of Nursing” Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.
1 citations
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January 2018 in “Recent clinical techniques, results, and research in wounds” Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.
150 citations
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June 2014 in “Biomaterials” Peptide hydrogels heal burn wounds faster and better than standard dressings.
17 citations
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August 2020 in “Stem Cell Research & Therapy” A 3D cell model can rejuvenate stem cells to improve wound healing.
Reprogramming adult fibroblasts may enable scar-free healing.
13 citations
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December 2012 in “Cells” Targeting the actin cytoskeleton could improve skin healing and reduce scarring.
10 citations
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July 2011 in “Wound Repair and Regeneration” New antiscarring strategies show promise, including drugs, stem cells, and improved surgical techniques.
5 citations
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February 2022 in “International Journal of Molecular Sciences” Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.
109 citations
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December 2003 in “American Journal of Pathology” Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.