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Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

Nandrolone and oxandrolone could help treat male health issues like muscle loss and low testosterone.

New treatments for male hypogonadism are easier to use and target specific tissues to reduce side effects.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Clinicians should use social and prescription data to track trends in performance-enhancing drug use.

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.

Estrogen therapy can reduce skin aging but has cancer risks.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.

The conclusion is that there is a high demand for new contraceptives that provide both pregnancy prevention and protection against STIs, along with additional health benefits.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Mutations in certain receptors can cause diseases and offer new treatment options.

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

Estrogen helps improve skin aging and healing, especially in post-menopausal women.

A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.

Using anabolic-androgenic steroids can harm men's reproductive health and increase the risk of heart problems and death.

Estrogen deficiency in postmenopausal women can cause skin and hair issues, but local estrogen therapies help improve vaginal health.

MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

Estrogen and androgen signals control synaptic changes in rat brains.

PROTACs offer a new, precise way to treat cancer by breaking down harmful proteins.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Targeting vitamin D and androgen receptors may effectively treat triple-negative breast cancer, especially with chemotherapy.