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Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Selenium Disulfide Shampoo

12 citations , July 1964 in “Archives of Dermatology”

Selenium sulfide shampoo doesn't affect hair growth or rest phases.

research Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

21 citations , April 2008 in “Toxicologic Pathology”

CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.

Long-Term Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Areata: Three-Year Results from the ALLEGRO Phase 2b/3 and ALLEGRO-LT Phase 3 Clinical Studies

research Long-Term Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Areata: 3-Year Results from the ALLEGRO Phase 2b/3 and ALLEGRO-LT Phase 3 Clinical Studies

March 2026 in “American Journal of Clinical Dermatology”

Ritlecitinib is effective and safe for long-term use in treating severe alopecia areata in people aged 12 and older.

Efficacy and Safety of Topical KX-826 in Male Subjects with Androgenetic Alopecia: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Study

research 587 Efficacy and Safety of topical KX-826 in Male Subjects with Androgenetic Alopecia:A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Study

November 2022 in “Journal of Investigative Dermatology”

KX-826 is safe and effectively increases hair count in men with hair loss.

Effect of Serenoa Repens Extract on Human Primary Hair Dermal Papilla Cells from Male and Female Donors

research Effect of a Serenoa repens extract on human primary hair dermal papilla cells isolated from male and female donors

March 2026 in “Planta Medica”

Serenoa repens extract may help hair growth in both men and women.

Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for Screening Steroid 5-Alpha Reductase in Human and Fish Cell Lines

research Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines

3 citations , February 2021 in “Molecules”

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

research Development of validated methods for the simultaneous quantification of Finasteride and Tadalafil in newly launched FDA-approved therapeutic combination: greenness assessment using AGP, analytical eco-scale, and GAPI tools

January 2023 in “RSC Advances”

The study developed accurate, precise, and environmentally friendly methods to measure Finasteride and Tadalafil in a new FDA-approved combination.

research Liquid Chromatography-Mass Spectrometry Based Isotopic Abundance Ratio Analysis of the Consciousness Energy Healing Treated L-Cysteine

March 2021 in “Juniper Online Journal Material Science”

Energy healing treatment improved L-cysteine's stability, solubility, bioavailability, and shelf-life.

research Clinical Trial of Finasteride on Alopecia X in a Dog

April 2009

research Safety and efficacy of a novel skin lightening agent for melasma

June 2017 in “Journal of The American Academy of Dermatology”

The new treatment was safe and may effectively treat male pattern hair loss.

Study of Thin Films and Nanoparticles Obtained by Self-Assembly of Block Copolymers and Their Interactions with an Oligo/Polysaccharide

research Study of thin films and nanoparticles obtained by self-assembly of block copolymers and their interactions with an oligo / polysaccharide

April 2011

The research found that nanoparticles coated with chitosan improved the skin penetration of the drug finasteride.

research Deep eutectic solvent-mediated local delivery of Cacumen Platycladi essential oil against androgenetic alopecia

October 2025 in “Chinese Chemical Letters”

Using a special solvent can make Cacumen Platycladi essential oil more effective for treating hair loss.

research SHP099-containing multi-targeting hydrogel promotes rapid skin reconstruction through modulating a variety of cells

April 2025 in “Frontiers in Bioengineering and Biotechnology”

Gel-SHP helps skin heal faster.

A One-Year Exploratory Randomized, Controlled, Multicentric Pilot Study Evaluating the Efficacy and Tolerance of an Anti-Hair Loss Serum Containing Silybum Marianum Extract, Manganese PCA, and Lespedeza Capitata Extract Following Hair Transplantation in Men with Androgenic Alopecia

research Supplementary file 1_A one-year exploratory randomized, controlled, multicentric pilot study evaluating the efficacy and tolerance of an anti-hair loss serum containing Silybum marianum extract, manganese PCA, and Lespedeza capitata extract following hair transplantation in men with androgenic alopecia.docx

June 2026 in “Figshare”

The serum improved hair growth and comfort after hair transplant.

research Mechanism of action of NLRP3 protein macromolecule based on electrochemical sensors in the treatment of alopecia areata in mice: The role of Ritlecitinib in AA mice through NLRP3

March 2026 in “Microchemical Journal”

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

research Plasma and Sonophoresis-Assisted Topical Delivery of an Exosome for Androgenic Alopecia

April 2026 in “Journal of Craniofacial Surgery”

The treatment improved hair growth and scalp health safely but needs more testing.

research Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

372 citations , December 2004 in “Nature Genetics”

research Triton modified polyethyleneimine conjugates assembled with growth arrest-specific protein 6 for androgenetic alopecia transdermal gene therapy

February 2023 in “Materials today bio”

The treatment effectively promotes hair regrowth in androgenetic alopecia without causing skin irritation.

research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

136 citations , April 2013 in “Clinical Cancer Research”

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

research ISID1441 – Platelet-rich plasma for treatment of androgenetic alopecia, effective or not? A review of the literature

April 2023

research Tamoxifen-induced androgenetic alopecia in a dialysis patient with sclerosing encapsulating peritonitis (SEP)

January 2004 in “Indian Journal of Nephrology”

research Discovery of a sol–gel reinforcing the strength of hair structure: mechanisms of action and macroscopic effects on the hair

2 citations , February 2016 in “Journal of sol-gel science and technology”

A small molecule can strengthen fine hair, making it more resistant and natural-feeling.

research ChemInform Abstract: Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α‐Reductase Inhibitor.

April 2011 in “ChemInform”

A new compound may effectively inhibit the enzyme linked to BPH and hair loss.

research A Patient Preference-Weighted Quantitative Benefit-Risk Analysis of Ritlecitinib for Alopecia Areata to Inform Medical Decision Making

September 2025 in “Value in Health”

Impact of a Topical Lotion, CG428, on Permanent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Pilot Randomized Double-Blind Controlled Clinical Trial (VOLUME RCT)

research Impact of a topical lotion, CG428, on permanent chemotherapy-induced alopecia in breast cancer survivors: a pilot randomized double-blind controlled clinical trial (VOLUME RCT)

3 citations , July 2019 in “Supportive Care in Cancer”

The lotion CG428 did not show effectiveness in treating permanent hair loss in breast cancer survivors.