research Spironolactone in combination drug therapy for unresponsive hirsutism
Combination drug therapy is effective for hirsutism that doesn't improve with just one medication.
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research Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess
Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.
research Finasteride-associated male infertility
Finasteride may cause male infertility, stopping it can help.
research Finasteride-induced secondary infertility associated with sperm DNA damage
Finasteride use may cause sperm damage and infertility, stopping it can improve sperm health.
research Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome
More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.
research Cardiometabolic risks in polycystic ovary syndrome: long-term population-based follow-up study
Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.
research Insulin resistance and its relationship with high molecular weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history of polycystic ovary syndrome
Teens with PCOS and a mom with PCOS have higher insulin resistance and lower adiponectin levels, which could signal early metabolic problems.
research Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome: lessons from a large database of two tertiary care centers on the Indian subcontinent
The oral glucose tolerance test is effective in detecting abnormal glucose tolerance in Indian women with PCOS.
research A variant of the glucocorticoid receptor gene is not associated with adrenal androgen excess in women with polycystic ovary syndrome
The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.
research Common urologic diseases in older men and their treatment: how they impact fertility
Urologic diseases and treatments in older men can negatively affect fertility, and doctors should talk to patients about this.
research Finasteride and male infertility: a case for prospective collaborative research databases?
Finasteride discontinuation increases sperm count in men.
research Rates of polycystic ovary syndrome (PCOS) symptoms in relatives of patients with PCOS
Female relatives of PCOS patients have a higher chance of showing PCOS symptoms.
research Use of Metformin versus Chromium Picolinate in the Management of Polycystic Ovarian Syndrome: A Randomized Controlled Clinical Trial
Chromium picolinate was better tolerated than metformin for PCOS with fewer side effects.
research The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrom patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function
Insulin resistance might not be enough to worsen blood vessel function in young, nonobese women with polycystic ovary syndrome.
research Effect of norplant on androgens and sexual function
Norplant implants lower some androgen levels but don't significantly change sexual function.
research Propecia-induced spermatogenic failure: a report of two cases
Stopping finasteride improved sperm counts in two men, reducing the need for fertility treatments.
research Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphisms
Metformin works better for adolescent girls with PCOS who have certain genetic variations.
research Fertility evaluation of infertile women: a committee opinion
The conclusion is that women under 35 should start fertility checks after 12 months of trying to conceive, women over 35 after 6 months, and women over 40 should start immediately. The checks should include ovulation status, reproductive tract structure, and male partner's semen evaluation.
research Male infertility and genitourinary birth defects: there is more than meets the eye
Male infertility and genitourinary birth defects are often linked to genetic issues.
research A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome
Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.
research A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women
A specific gene variation is linked to a higher risk of polycystic ovary syndrome in Caucasian women.
research Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome
The 2023 guideline for PCOS suggests using updated diagnostic criteria, assessing related health risks, and recommends lifestyle changes and specific treatments for symptoms and fertility issues.
research The association of medications and supplements with human male reproductive health: a systematic review
Some medications and supplements can affect male fertility, with some improving and others harming sperm quality.
research Chapter 4 Cytomechanics of Hair
Hair's strength and flexibility come from its protein structure and molecular interactions.
research Finasteride
Finasteride helps hair growth.
research Testosterone implants in women: Pharmacological dosing for a physiologic effect
Testosterone implants in women require pharmacological dosing to be effective and are generally safe and well-tolerated.
research Endometrioid adenofibroma arising in an endometriotic cyst
A woman's pelvic pain and bleeding led to finding and successfully treating a rare benign tumor in her reproductive system.
research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.
Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
research OPTIMIZATION OF NANO GEL FORMULATION BASED ON BANGKAL (NAUCLEA SUBDITA) WOOD BARK EXTRACT AND ANTIBACTERIAL ACTIVITY AGAINST PROPIONIBACTERIUM ACNES
The nanogel with Bangkal bark extract effectively fights acne-causing bacteria.
research Polycystic ovary syndrome and insulin-resistant hyperinsulinemia
Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.