Nanotechnology-Based Strategies for Hair Regeneration: Mechanistic Insights and Translational Perspectives for Androgenetic Alopecia
January 2026
in “
Preprints.org
”
nanotechnology androgenetic alopecia targeted drug delivery hair follicles controlled drug release follicular microenvironment nanocarrier design nano-enabled microneedle systems multifunctional nanomaterials oxidative stress angiogenesis inflammation hair follicle stem cell activity minoxidil finasteride AGA Rogaine Propecia
TLDR Nanotechnology shows promise for treating hair loss but faces safety and approval challenges.
Recent advancements in nanotechnology offer promising strategies for managing androgenetic alopecia (AGA), the most common form of hair loss. These strategies focus on targeted drug delivery to hair follicles, controlled drug release, and modulation of the follicular microenvironment. Key areas of progress include nanocarrier design, nano-enabled microneedle systems, and multifunctional nanomaterials that regulate oxidative stress, angiogenesis, inflammation, and hair follicle stem cell activity. Despite the potential of these approaches to overcome the limitations of current FDA-approved therapies like minoxidil and finasteride, challenges remain in terms of safety, manufacturing, and regulatory approval for clinical use.
