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GlossaryHair Follicles

small skin structures from which hair grows

Hair follicles are small, tunnel-like structures in the skin from which hair grows. Each follicle anchors a single hair into the skin and is composed of several layers, including the bulb at the base where cells divide and grow to build the hair shaft. These structures also contain sebaceous glands that produce oil to condition the hair and skin.

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Analysis of Gene Expression in Isolated Single Hair Follicles Using Semiquantitative Reverse-Transcriptase Polymerase Chain Reaction

research Analysis of Gene Expression in Isolated Single Hair Follicles: An Approach Using Semiquantitative Reverse-Transcriptase—Polymerase Chain Reaction

May 1995 in “Journal of Investigative Dermatology”

Researchers developed a new way to measure gene activity in single hair follicles and found that a specific gene's activity changes with different amounts and times of treatment.

Integrating Single-Cell and Spatial Transcriptomics of Human Hair Follicles to Define Transcriptional Signature of Follicular Dermal Papilla

research 189 Integrating single-cell and spatial transcriptomics of human hair follicles to define transcriptional signature of follicular dermal papilla

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The research identified specific genes that are active in the cells crucial for hair growth.

research Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying

13 citations , May 2022 in “Cell discovery”

The study found new details about human hair growth and suggests that preventing a specific biological pathway could potentially treat hair graying.

research The feasibility of quantitative analysis of androgen metabolism by use of single dermal papillae from human hair follicles

4 citations , April 2001 in “Experimental Dermatology”

Using single dermal papillae is unreliable for analyzing androgen metabolism in hair follicles.

research 655 In vitro cultivation of dermal-epidermal composites in a single medium supports human hair follicle neogenesis in xenografts

July 2024 in “Journal of Investigative Dermatology”

A single medium, PRIME AIRLIFT, supports better human hair follicle formation in grafts.

Single Follicular Unit Transplantation Reconstructs Arrector Pili Muscle and Nerve Connections and Restores Functional Hair Follicle Piloerection

research Single follicular unit transplantation reconstructs arrector pili muscle and nerve connections and restores functional hair follicle piloerection

13 citations , March 2012 in “The Journal of Dermatology”

Hair transplant surgery can rebuild muscle and nerve connections, allowing transplanted hairs to stand up like normal hairs.

research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

10 citations , December 2021 in “Frontiers in cell and developmental biology”

The research identified genes that explain why some sheep have curly wool and others have straight wool.

research Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing

8 citations , December 2022 in “BMC Genomics”

The research improved understanding of yak hair growth to help use yak wool better.

research Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging

3 citations , July 2023 in “Frontiers in Aging”

Hair follicle stem cells change states with age, affecting hair growth and aging.

research Single dose gamma irradiation induced angiogenesis in rat skin hair follicles

3 citations , October 2020 in “Internatuinal Journal of Radiation Research”

Gamma irradiation can stimulate hair growth by promoting new blood vessel formation.

research Single-cell sequencing reveals the new existence form of dermal papilla cells in the hair follicle regeneration of cashmere goats

2 citations , February 2022 in “Genomics”

Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.

research A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis

1 citations , January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research mapped out the cell types and molecular processes involved in developing Cashmere goat hair follicles.

research A single-cell transcriptomic atlas elucidates the hair cycle and apoptosis mechanisms in goat hair follicles

November 2025 in “Frontiers in Cell and Developmental Biology”

The study maps goat hair follicle cells, revealing key genes and pathways involved in hair growth and cell death.

Single-Cell Sequencing Reveals the Intermediate Cell State and Function of Dermal Papilla Cells in the Hair Follicle Cycle of Cashmere Goats

research Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats

May 2020 in “Research Square (Research Square)”

Researchers found four key stages of cell development that are important for hair growth and shedding in cashmere goats.

research Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin

18 citations , August 2015 in “International Journal of Molecular Sciences”

Ovine hair follicle stem cells can regenerate haired skin and may improve wool production.

research A single arm, exploratory and pilot study to evaluate the efficacy of a multi-component water-based herbal supplement in hair growth, density, follicle strength and hair fall in healthy male and female subjects

September 2021 in “IP Indian Journal of Clinical and Experimental Dermatology”

The herbal supplement improved hair growth, density, and strength without side effects.

Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

10 citations , July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.

research Bottom-up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration

30 citations , December 2017 in “Advanced Healthcare Materials”

Nanoencapsulation creates adjustable cell clusters for hair growth.

research Laser microdissection and DNA typing of cells from single hair follicles

45 citations , December 2004 in “Forensic Science International”

Laser microdissection helps get DNA from single hair follicles for better forensic analysis.

research 0140 Delineating key molecular programs that induce hair-follicle-inductive dermal fibroblasts using a novel single-cell genomic approach

July 2025 in “Journal of Investigative Dermatology”

Wnt and SHH pathways help form hair follicles by coordinating cell processes.

Cytokine Loaded Layer-By-Layer Ultrathin Matrices to Deliver Single Dermal Papilla Cells for Spot-By-Spot Hair Follicle Regeneration

research Cytokine loaded layer-by-layer ultrathin matrices to deliver single dermal papilla cells for spot-by-spot hair follicle regeneration

19 citations , December 2015 in “Journal of Materials Chemistry B”

Scientists have created a method to deliver specific cells that can regenerate hair follicles, potentially offering a new treatment for hair loss.

research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles

November 2024 in “Stem Cell Research & Therapy”

A new method improves the isolation of hair follicle cells for better hair growth research.

research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging

September 2017 in “Journal of Investigative Dermatology”

RCS-01 is safe and may help rejuvenate aging skin.

Force-Triggered Density Gradient Sedimentation and Cocktail Enzyme Digestion Treatment for Isolation of Single Dermal Papilla Cells from Follicular Unit Extraction Harvesting Human Hair Follicles

research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles

October 2024

New methods efficiently isolate dermal papilla cells from hair follicles, preserving their characteristics better than traditional methods.

research Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation

77 citations , February 2001 in “Journal of Dermatological Science”

HGF activator helps convert HGF to its active form, promoting hair growth.

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Related Terms

Research

research Analysis of Gene Expression in Isolated Single Hair Follicles: An Approach Using Semiquantitative Reverse-Transcriptase—Polymerase Chain Reaction

research 189 Integrating single-cell and spatial transcriptomics of human hair follicles to define transcriptional signature of follicular dermal papilla

research Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying

research The feasibility of quantitative analysis of androgen metabolism by use of single dermal papillae from human hair follicles

research 655 In vitro cultivation of dermal-epidermal composites in a single medium supports human hair follicle neogenesis in xenografts

research Single follicular unit transplantation reconstructs arrector pili muscle and nerve connections and restores functional hair follicle piloerection

research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

research Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing

research Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging

research Single dose gamma irradiation induced angiogenesis in rat skin hair follicles

research Single-cell sequencing reveals the new existence form of dermal papilla cells in the hair follicle regeneration of cashmere goats

research A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis

research A single-cell transcriptomic atlas elucidates the hair cycle and apoptosis mechanisms in goat hair follicles

research Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats

research Ovine Hair Follicle Stem Cells Derived from Single Vibrissae Reconstitute Haired Skin

research A single arm, exploratory and pilot study to evaluate the efficacy of a multi-component water-based herbal supplement in hair growth, density, follicle strength and hair fall in healthy male and female subjects

research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

research Bottom-up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration

research Laser microdissection and DNA typing of cells from single hair follicles

research 0140 Delineating key molecular programs that induce hair-follicle-inductive dermal fibroblasts using a novel single-cell genomic approach

research Cytokine loaded layer-by-layer ultrathin matrices to deliver single dermal papilla cells for spot-by-spot hair follicle regeneration

research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles

research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging

research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles

research Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation

research Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

research In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide‐directed gene targeting

research 1338 Dermal Wnt/β-catenin activation tunably controls hair follicle initiation

research In vivo Alteration of the Keratin 17 Gene in Hair Follicles by Oligonucleotide-directed Gene Targeting

research The molecular anatomy of cashmere goat hair follicle during cytodifferentiation stage