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A molecule called α-ketobutyrate was found to extend lifespan and improve aging-related symptoms in worms and mice by activating certain cellular pathways and may help develop anti-aging treatments for humans.

NKIRAS2 can suppress certain skin tumors but its effect on cancer varies with context and expression level.

Sry may regulate fatty acid metabolism and shows different expression levels in rat tissues.

Overexpressing SSAT in mice makes them highly sensitive to polyamine analogues, causing liver damage and high mortality.

Transglutaminase 2 may control sebocyte maturation and lipid metabolism.

SFRP2 boosts Wnt3a/β-catenin signals in hair growth cells, with stronger effects in beard cells than scalp cells.

Understanding snoRNA regulation may help slow skin aging.

Loss of Rap1 protein speeds up heart aging in mice.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

Keeping human skin stem cells is easier with low temperatures and mTOR inhibition.

TEDAR is crucial for skin cell differentiation and barrier formation.

TSC22D genes are key in metabolic diseases and cancer, offering potential as treatment targets.

Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.

The gene NM_026333 slows down aging by affecting the NCX1 pathway and could be targeted for anti-aging treatments.

Syndecan-1 is essential for maintaining skin fat and preventing cold stress.

Lack of TG2 increases fat storage and lowers cell cleanup in skin oil cells.

ETS2 drives cancer progression in squamous cell carcinoma and is linked to poor patient outcomes.

Increased energy use in Pik3r1-related insulin resistance isn't due to Ucp1 thermogenesis.

Calorie restriction boosts stem cell activity, improving tissue regeneration and lifespan.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

ETS2 is crucial in squamous cell carcinoma development and could be a therapeutic target.

CTIP2 may help in skin development and maintenance.

Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

EGM2 and SOX2 help form beige adipocytes by maintaining ASC immaturity and activating brown adipocytes.

Targeting protein S-palmitoylation could lead to new skin disease treatments.

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

TLR2 is important for hair growth and can be targeted to treat hair loss.