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research Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex

77 citations , April 2005 in “Journal of Investigative Dermatology”

Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.

research Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation

49 citations , November 2013 in “The Journal of Steroid Biochemistry and Molecular Biology”

Vitamin D receptor helps control skin cell growth and hair development.

research Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo

46 citations , May 2003 in “Mechanisms of Development”

Increasing calcium sensing receptor speeds up skin and hair development in mice.

research Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression

37 citations , February 2005 in “Journal of Investigative Dermatology”

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

research Merkel cell differentiation in trichoblastoma

34 citations , January 1998 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin”

Trichoblastomas may mimic fetal skin development by having many Merkel cells, unlike adult skin.

research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

research Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis

12 citations , December 2022 in “Frontiers in Bioscience-Landmark”

The role of certain genes in skin cell development may be linked to psoriasis, but the connection is unclear.

research 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

Dermal Fibroblasts Enhance Growth Factors Production by Androgens and Modulate Keratinocyte Proliferation and Differentiation

research 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Androgens increase growth factors in skin cells, which may lead to acne.

research Claudin tight junctionwhat's your function? The role of Claudin 6 in epidermal and hair follicle differentiation

January 2004 in “uO Research (University of Ottawa)”

Claudin 6 is crucial for normal skin and hair development.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

3 citations , January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

research Nuclear Topology, Epigenetics, and Keratinocyte Differentiation

2 citations , August 2013 in “Journal of Investigative Dermatology”

Nuclear shape and chromatin changes affect gene expression in skin cell differentiation.

research Cellular localization of retinoic acid receptor-gamma expression in normal and neoplastic skin.

23 citations , June 1992 in “PubMed”

RAR-gamma 1 is important for normal skin maintenance and differentiation.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations , January 2011 in “PloS one”

Notch signaling is essential for healthy skin and hair follicle maintenance.

$Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation$

research Human keratinocytes derived from the bulge region of hair follicles are refractory to differentiation

8 citations , April 2009 in “International journal of oncology”

Hair follicle cells resist turning into skin cells.

research Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene ID2, by contact sensitizers in human bulge‐derived keratinocytes

6 citations , January 2010 in “Journal of Biochemical and Molecular Toxicology”

The ID2 gene can help distinguish between sensitizers and irritants in skin cells.

research L-borneol regulates rno-miR-127/ PODXL2 to promote hair follicle stem cells to repair skin wounds

1 citations , May 2025 in “International Immunopharmacology”

L-borneol helps skin wound healing by promoting stem cell differentiation.

research Abstract 5219: The role of MEK and Antizyme in keratinocyte stem cell expansion and differentiation

1 citations , April 2012 in “Cancer Research”

Antizyme reduces tumor growth and normalizes skin cell development affected by MEK.

research In vitro Differentiation of Melanocyte Stem Cells Derived from Vitiligo Patients into Functional Melanocytes

April 2024 in “The Indonesian Biomedical Journal”

Melanocyte stem cells from non-affected skin in vitiligo patients can become functional melanocytes for potential therapy.

research p63 expression in normal skin and usual cutaneous carcinomas

157 citations , October 2002 in “Journal of Cutaneous Pathology”

p63 may influence skin cancer development and cell differentiation.

research IMMUNOHISTOCHEMICAL DEMONSTRATION OF POLY(ADENOSINE DIPHOSPHATE‐RIBOSE) SYNTHESIS IN HUMAN SKIN

13 citations , April 1982 in “The Journal of Dermatology”

Poly(ADP-ribose) synthesis is linked to skin cell differentiation.

research Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.

79 citations , June 1993 in “Molecular and Cellular Biology”

The K5 promoter controls gene expression in skin cells, with specific DNA segments crucial for targeting and regulation.

research Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures

67 citations , June 2019 in “Proceedings of the National Academy of Sciences”

A new 3D culture system helps grow and study mouse skin stem cells for a long time.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets.

39 citations , January 2016 in “PubMed”

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations , August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin

10 citations , October 2019 in “Iranian Biomedical Journal”

Simvastatin helps hair follicle stem cells turn into skin cells.

research [An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies].

6 citations , December 1990 in “PubMed”

Keratinocytes in hair follicles differentiate similarly to skin cells, with specific patterns in different regions.

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