103 citations
,
January 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
94 citations
,
August 1975 in “Journal of Cutaneous Pathology” Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.
89 citations
,
April 2020 in “Advanced Healthcare Materials” MSC-laden hydrogels enable scarless wound healing with hair growth.
86 citations
,
August 2000 in “Pigment cell research” Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.
84 citations
,
January 1990 in “Journal of The American Academy of Dermatology” Skin grafting can help repigment vitiligo, but it's less effective for widespread cases due to the Koebner phenomenon.
83 citations
,
September 2021 in “Advanced functional materials” The DNA hydrogel helps heal diabetic wounds by absorbing fluids, warming, sticking to tissue, killing bacteria, and aiding tissue and hair regrowth.
81 citations
,
October 2023 in “Bioactive Materials” 3D-printed microneedles improve drug delivery and diagnostics but face scalability and regulatory challenges.
72 citations
,
November 2002 in “Journal of Investigative Dermatology” Estrogen receptor α controls hair growth cycles and skin thickness in male mice.
62 citations
,
January 2000 in “Developmental dynamics” Notch-related genes play a key role in the development and cycling of hair follicles.
59 citations
,
September 2007 in “Biochemical and Biophysical Research Communications” The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.
51 citations
,
August 2013 in “Journal of Investigative Dermatology” Human skin cells can create new hair follicles when transplanted into mice.
48 citations
,
July 2019 in “International Journal of Biological Macromolecules” A new hydrogel with stem cells from human umbilical cords improves skin wound healing and reduces inflammation.
45 citations
,
May 2003 in “Journal of Cell Science” α3β1-integrin is crucial for maintaining normal hair follicle shape and function but not needed for the development of the surrounding skin.
44 citations
,
March 2004 in “Journal of Investigative Dermatology” The effects of estrogen on human hair growth are unclear and need more research.
44 citations
,
January 2004 in “American journal of clinical dermatology” Understanding genetic mutations helps diagnose and treat skin disorders like ichthyosis.
42 citations
,
January 2014 in “Cold Spring Harbor Perspectives in Medicine” Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.
37 citations
,
October 2009 in “Dermatology” Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.
33 citations
,
September 2019 in “Dermatologic Surgery” Using a special stem cell formula on the scalp once a month for six months helped people with hair loss grow more hair.
32 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” 17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.
31 citations
,
January 2014 in “The Scientific World JOURNAL” Eclipta prostrata extract protects skin cells from UVB damage and has strong antioxidant properties.
26 citations
,
November 2016 in “Current pharmaceutical design” Ginseng may be beneficial for skin health and treating various skin conditions.
26 citations
,
April 1999 in “Dermatologic Clinics” The long-pulsed alexandrite laser is effective for hair reduction, particularly for light-skinned individuals with dark hair, but caution is needed for darker skin.
21 citations
,
April 2019 in “Journal of cosmetic and laser therapy” Laser hair removal is popular for long-term hair reduction but carries risks, requiring well-trained operators and better regulations, especially in South Africa.
19 citations
,
April 2020 in “Journal of ethnopharmacology” Prunus mira nut oil helps hair grow by affecting the Wnt/β-catenin signaling pathway.
19 citations
,
April 2015 in “International Journal of Molecular Sciences” The research identified genes and pathways important for sheep wool growth and shedding.
19 citations
,
February 1998 in “Cellular Immunology” Hair growth phase in mice weakens certain immune responses.
18 citations
,
October 2019 in “Advanced Pharmaceutical Bulletin” Microemulsions can improve skin delivery of finasteride.
18 citations
,
January 2020 in “Ecology and evolution” Genes related to pigmentation, body rhythms, and behavior change during hares' seasonal coat color transition, with a common genetic mechanism in two hare species.
17 citations
,
May 2011 in “Gene Therapy” Using polyethylenimine-DNA to deliver the hTERT gene can stimulate hair growth and may be useful in treating hair loss, but there could be potential cancer risks.
17 citations
,
December 2001 in “Journal of Investigative Dermatology” The osteopontin gene is active in a specific part of rat hair follicles during a certain hair growth phase and might affect hair cycle and diseases.