research Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function
Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.
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300-330 / 1000+ results research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs
Laminin 332 is essential for normal skin cell behavior and structure.
research Particularidades dermatológicas, fisiológicas e as dermatoses na pele negra
Black skin has unique features and conditions, needing tailored dermatological care.
research LB1077 Cutaneous responses to systemic iron: A potential role for epidermal turnover in mammalian iron excretion
Skin may help in getting rid of excess iron through the process of skin cell renewal.
research LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy
The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.
research In focus in HCB
The May issue discussed publishing agreements and four studies on cholesterol in hair, cancer cell changes, hormones in the uterus, and skin protein effects.
research 0952 Spatial transcriptomics reveal compartmentalized dysregulation of lipid metabolism in acne vulgaris
Acne involves increased lipid production and inflammation, affecting skin cell behavior and treatment resistance.
research TMT-based quantitative proteomics reveals the genetic mechanisms of secondary hair follicle development in fine-wool sheep
Key proteins influence wool quality by affecting hair follicle development in sheep.
research Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways
Camellia sinensis seed flavonoids can reduce skin inflammation and damage from UV rays.
research Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation
Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.
research Clinical Case Notes. Intraorbital ophthalmic artery aneurysms
Eye exams are crucial for kids with 13q deletion syndrome, tamoxifen can cause vision loss, Propecia may lead to cataracts, Lipoid Proteinosis causes skin bumps, and OCT is useful for diagnosing macular diseases.
research Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis
Lack of Evi in skin causes psoriasis-like symptoms in mice.
research Abstracts
New treatments and diagnostic methods for various animal skin conditions showed promising results.
research The epidermis: rising to the surface
The document concludes that recent research has improved understanding of skin diseases and the balance between cell growth and differentiation in the epidermis.
research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
research Formation and Structure of Human Hair
Human hair growth and structure are influenced by keratin proteins, genes, melanin, and lipids.
research Mechanical and biological properties of keratose biomaterials
Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.
research Type XVII collagen coordinates proliferation in the interfollicular epidermis
Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.
research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition
The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
Hairless protein can block vitamin D activation in skin cells.
research Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair
Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.
research Wnt signaling: the good and the bad
Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.
research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility
Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.
research Tuning Wnt Signals for More or Fewer Hairs
Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
research The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics
Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.
research The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine
A new skin-whitening agent using a peptide from wheat is safe and effective at reducing skin pigmentation.
research Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth
The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.
research IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes
A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.
research Inherited epidermolysis bullosa: clinical and therapeutic aspects
The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.
research Cutaneous Drug Delivery: An Update
New methods like nanoparticles and microneedles show promise for better skin drug delivery, especially for hair disorders.