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Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

research Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

November 2023 in “Life”

Eriocitrin and silymarin might be effective for hair loss treatment and need more research.

research Comparison of the pharmacoeconomic profiles of treatment regimens for field pattern actinic keratoses

April 2016 in “Journal of The American Academy of Dermatology”

Some blood pressure medications are linked to a higher risk of skin cancer.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research Case of alopecia induced by sorafenib, possible mechanism similar to alopecia areata

4 citations , November 2017 in “The Journal of Dermatology”

Sorafenib may cause hair loss in a way similar to alopecia areata.

research Therapeutic Androgen Receptor Ligands

16 citations , January 2003 in “Nuclear Receptor Signaling”

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

research S100A8 induces cyclophosphamide-induced alopecia via NCF2/NOX2-mediated ferroptosis

2 citations , February 2025 in “Free Radical Biology and Medicine”

Blocking S100A8 can reduce chemotherapy-induced hair loss.

Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

research Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety

7 citations , August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

research ISID1116 – Novel androgen receptor degrader for androgenetic alopecia (AGA) application

May 2023

research Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

21 citations , April 2008 in “Toxicologic Pathology”

CI-1033 causes skin lesions in rats, similar to humans, due to EGF receptor inhibition.

research Pantolactams as androgen receptor antagonists for the topical suppression of sebum production

5 citations , September 2011 in “Bioorganic & Medicinal Chemistry Letters”

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations , May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

Inhibition of the Hippo Pathway by Verteporfin Reduces the Proliferation and Stemness of Rat Hair Follicle Neural Crest Stem Cells Under Hypoxia

research Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia

February 2025 in “FASEB BioAdvances”

Verteporfin reduces growth and stem cell traits in rat hair follicle cells by blocking the Hippo pathway.

research Finasteride Inhibits Human Prostate Cancer Cell Invasion through MMP2 and MMP9 Downregulation

63 citations , December 2013 in “PLoS ONE”

Finasteride may reduce prostate cancer spread by lowering certain enzyme levels.

research A Soy-Derived Immunostimulating Peptide Inhibits Etoposide-Induced Alopecia in Neonatal Rats

17 citations , March 2004 in “Journal of Investigative Dermatology”

Soymetide-4 from soy can prevent hair loss caused by a cancer drug in rats.

research Three Considerations Before Advising 5-α-Reductase Inhibitors for Chemoprevention

6 citations , June 2009 in “Journal of Clinical Oncology”

5-α-reductase inhibitors don't prevent prostate cancer but may reduce unnecessary biopsies.

research The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer

108 citations , February 2008 in “The Journal of urology/The journal of urology”

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

research 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia

1 citations , November 2022 in “Journal of Investigative Dermatology”

ALRN-6924 may prevent hair loss caused by chemotherapy.

research Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor

44 citations , December 2005 in “The Journal of Steroid Biochemistry and Molecular Biology”

Combining 5α-reductase and aromatase inhibitors may better reduce estrogen levels.

A Meta-Analysis of the Effectiveness and Safety of Sintilimab Combined with Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer

research A meta-analysis of the effectiveness and safety of Sintilimab combined with chemotherapy in the trea tment of advanced non-small cell lung cancer

July 2024

Sintilimab with chemotherapy improves survival and response in advanced lung cancer but increases some side effects.

research Pharmacophore and Atom Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors

2 citations , November 2018 in “Indian Journal of Pharmaceutical Education”

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

research Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor

18 citations , October 2010 in “Bioorganic & Medicinal Chemistry Letters”

New hybrid compound found to effectively prevent hair loss.

research Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

23 citations , December 2013 in “Molecular cancer therapeutics”

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

research Is sulfonamide group of tamsulosin main factor in the pathophysiology of floppy iris syndrome?

January 2018 in “Haydarpaşa Numune Hastanesi tıp dergisi”

Tamsulosin's sulfonamide group may contribute to floppy iris syndrome.

research The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases

70 citations , October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.