76 citations
,
July 2009 in “Neuroscience” Neurosteroids like allopregnanolone help control cell death and growth in the developing fetal brain.
2 citations
,
March 2017 in “Canadian Urological Association journal” Clomiphene citrate improves fertility in men taking finasteride for hair loss.
8 citations
,
February 2014 in “General and Comparative Endocrinology” Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
42 citations
,
February 1996 in “Journal of Investigative Dermatology” Polyamines, especially spermidine, are essential for hair growth.
April 2026 in “The Journal of Urology” Finasteride and dutasteride reduce semen quality, with dutasteride having a stronger negative effect.
16 citations
,
January 2017 in “Asian journal of andrology/Asian Journal of Andrology” Men who start puberty later may have lower sperm quality and different hormone levels in adulthood.
37 citations
,
January 2009 in “Sexual Development” Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.
9 citations
,
March 2023 in “Chemosphere” Certain pesticides may delay sexual maturity in teenage boys.
April 2023 in “Journal of Investigative Dermatology” ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.
1 citations
,
November 2016 in “Congenital Anomalies” Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.
Finasteride may affect female fertility by altering gene activity.
August 2011 in “Reproductive Toxicology”
12 citations
,
October 2012 in “International Braz J Urol” Finasteride effectively and safely treats recurrent priapism in children and adolescents with sickle cell disease.
6 citations
,
October 1993 in “Endocrinology” Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.
16 citations
,
March 2020 in “Animal Biotechnology” Transgenic sheep embryos with a specific promoter were successfully created, but more research is needed for gene expression in hair follicles.
October 2023 in “Bangladesh journal of urology” Finasteride effectively treats hematospermia in 3 months without side effects.
October 2017 in “Journal of The European Academy of Dermatology and Venereology” Stem cells preservation in AGA could be a potential therapy, but more cases needed.
April 2020 in “The FASEB Journal” Finasteride may cause lasting sexual issues by altering specific genes in human cells.
14 citations
,
June 1995 in “The Journal of Clinical Endocrinology and Metabolism” 1 citations
,
November 2022 in “Journal of Investigative Dermatology” ALRN-6924 may prevent hair loss caused by chemotherapy.
2 citations
,
March 2025 in “Cancer Gene Therapy” Targeting Sirt1 can reduce androgen levels and slow glioblastoma growth.
99 citations
,
August 2009 in “Nature Genetics” Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.
36 citations
,
June 2001 in “Neuroscience Letters” Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.
A stable sheep ovarian cell line was created for studying reproduction and hormones.
April 2020 in “Journal of the Endocrine Society” A 14-year-old girl with no menstrual period was diagnosed with Swyer Syndrome and treated for a related cancer risk.
Finasteride improves hair but may reduce sperm quality at higher doses.
72 citations
,
September 1975 in “Biology of Reproduction” Most zinc in rat sperm is in the tail, linked to structures similar to hair keratin.
2 citations
,
November 2025 in “Journal of Ovarian Research” Reducing granulosa cell pyroptosis may improve oocyte maturation in PCOS.
51 citations
,
August 2012 in “Differentiation” Mouse genital development depends on male or female hormones for specific features.
June 2021 in “Archives of Advances in Biosciences” Finasteride reduces sperm count and quality and alters hormone levels in mice.