58 citations
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December 2020 in “Mayo Clinic Proceedings” The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.
54 citations
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June 2015 in “Australasian Journal of Dermatology” Spironolactone is an effective and well-tolerated first-line treatment for hidradenitis suppurativa in women.
54 citations
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February 1986 in “Archives of Dermatology” Higher minoxidil concentration (5%) works better for severe hair loss, with most patients seeing regrowth in 48-60 weeks.
53 citations
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October 1993 in “Drug Safety” Oral retinoids can cause side effects ranging from mild to severe, including birth defects, and require careful monitoring and contraception.
50 citations
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July 1996 in “Fertility and Sterility” Finasteride effectively treats hirsutism in women, but more research needed for long-term results.
42 citations
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January 2011 in “Journal of Biomedical Optics” Infrared and Raman imaging can non-destructively analyze hair structure and help diagnose hair conditions.
41 citations
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March 2007 in “Steroids” New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
34 citations
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October 2018 in “Journal of The American Academy of Dermatology” Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.
34 citations
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February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.
33 citations
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December 2015 in “Neuroendocrinology” Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.
33 citations
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December 2012 in “NMR in Biomedicine” Microencapsulation helps protect and track therapeutic cells, showing promise for treating various diseases, but more work is needed to improve the technology.
32 citations
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February 2019 in “Journal of neurochemistry” Sex hormones affect brain injury differently in males and females.
32 citations
,
October 2003 Spironolactone is better than placebo for reducing excessive hair growth in women, but its effectiveness for acne is unclear due to small study sizes.
31 citations
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September 2006 in “International journal of gynaecology and obstetrics” New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.
30 citations
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April 2007 in “Dermatologic Clinics” The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.
30 citations
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January 2000 in “Dermatologic Clinics” Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.
30 citations
,
February 1994 in “Journal of Cutaneous Pathology” A woman's hair loss was initially mistaken for a common hair loss condition but was later found to be caused by breast cancer cells in her scalp.
27 citations
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January 2017 in “Neuropsychopharmacology” The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.
25 citations
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July 2013 in “Environmental Toxicology and Chemistry” Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.
25 citations
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April 2012 in “Acta Biomaterialia” Using certain small proteins with a growth factor and specific materials can increase the creation of neurons from stem cells.
24 citations
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October 2024 in “Process Biochemistry” Optimal conditions for extracting beneficial compounds from Carthamus caeruleus L. rhizomes were identified, improving efficiency.
24 citations
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May 2015 in “Schizophrenia Research” A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.
24 citations
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December 2013 in “Sexual medicine reviews” Finasteride can cause sexual problems and depression in young men.
24 citations
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July 2012 in “Current Opinion in Obstetrics & Gynecology” Early diagnosis and treatment are key to managing health risks in teens with PCOS.
24 citations
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February 1987 in “Drugs” Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.
23 citations
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May 2019 in “Expert Opinion on Therapeutic Patents” New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.
22 citations
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October 2019 in “Cerebral cortex” Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.
22 citations
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January 2002 in “Treatments in endocrinology” Birth control pills help treat skin and hair growth problems linked to high male hormone levels.
21 citations
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January 2020 in “General and Comparative Endocrinology” Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
20 citations
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November 2019 in “Biomolecules” Finasteride reduces response to stress and rewards, affecting behavior and mental health.