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Comparative Study on Eucalyptol and Camphor Rich Essential Oils from Rhizomes of Hedychium Spicatum and Their Pharmacological, Antioxidant, and Antifungal Activities

research Comparative study on eucalyptol and camphor rich essential oils from rhizomes of Hedychium spicatum Sm. and their pharmacological, antioxidant and antifungal activities

7 citations , January 2022 in “Anais Da Academia Brasileira De Ciencias”

Essential oils from Hedychium spicatum have potential for developing natural drugs with pain-blocking, fever-reducing, anti-inflammatory, and antioxidant properties.

research Towards sustainable and scalable synthesis of amitriptyline hydrochloride, minoxidil, and pyrrolidinyl diaminopyrimidine oxide

1 citations , May 2025 in “Journal of the Indian Chemical Society”

research Tuning Scaffold Properties of New 1,4-Substituted Pyrrolo[3,2-c]quinoline Derivatives Endowed with Anticancer Potential, New Biological and In Silico Insights

December 2025 in “Biomolecules”

Compound 7p shows strong potential as an anticancer agent.

research Atroposelective Synthesis of Biaryl N‐Oxides via Cu‐Catalyzed De Novo Heteroaromatic N‐Oxide Ring Formation

6 citations , August 2024 in “Advanced Science”

A new method efficiently creates biaryl N-oxides with potential for cancer treatment and drug development.

Synthesis of Analogues of Cercidin, an Antimicrobial Compound of Cercidiphyllum Japonicum: Glycosylation of Methyl Gallate with Ulosyl Bromides

research Synthesis of Analogues of Cercidin, an Antimicrobial Compound of Cercidiphyllum japonicum : Glycosylation of Methyl Gallate with Ulosyl Bromides

June 2025 in “Natural Product Communications”

Researchers created 10 new compounds similar to cercidin, which could lead to new antibiotics.

research 2,5-Diazabicyclo[2.2.1]heptane in medicinal chemistry: a treasure trove of therapeutic opportunities

January 2026 in “RSC Medicinal Chemistry”

2,5-DBH shows promise for improving drugs in cancer, brain disorders, and infections.

Ultrasound-Assisted Facile Synthesis and Anticancer Evaluation of Novel N-(2-Substituted Phenyl-4-Oxathiazolidine-3-Carbonothioyl) Benzamide

research Ultrasound-Assisted Facile Synthesis and Anticancer Evaluation of Novel N-(2-substituted phenyl-4-oxathiazolidine-3-carbonothioyl) benzamide

November 2018

Researchers made new compounds that could potentially be developed into anticancer drugs.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Indole Glycosides from Calanthe discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells

3 citations , April 2021 in “Chemical & Pharmaceutical Bulletin”

Extracts from the Calanthe discolor plant promote hair follicle growth and increase growth factor levels.

research Selective isomerization of α-pinene oxide to campholenic aldehyde by ionic liquid-supported indenyl-molybdenum(II)-bipyridine complexes

6 citations , May 2022 in “Journal of Organometallic Chemistry”

The process efficiently converts α-pinene oxide to campholenic aldehyde using a special catalyst, achieving high yields quickly.

research Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines

January 2023 in “IntechOpen eBooks”

The document concludes that specific methods for making diazine-based drugs can lead to high yields and are important for creating effective treatments for various diseases.

research Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process

13 citations , May 2011 in “Bioorganic & Medicinal Chemistry”

Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity

13 citations , October 2017 in “Bioorganic & Medicinal Chemistry”

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research Recent advances in thiasteroids chemistry

37 citations , October 2006 in “Steroids”

New sulfur-containing steroid analogs show promise for more targeted medical treatments.

research Estudio de la reactividad de los anillos A y C de olean-12-enos naturales para la obtención de sintones quirales

January 2003 in “Dialnet (Universidad de la Rioja)”

The study found ways to create important compounds for male health from olive waste.

research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-methylpregna-4,6-diene-3,20-dione

2 citations , October 2001 in “Analytical Sciences”

A new compound that could treat various androgen-related conditions was created and analyzed.

research Stereocontrolled synthesis of all eight stereoisomers of the putative anti-androgen cyoctol

16 citations , August 2004 in “Tetrahedron”

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Crystal Structure and Synthesis of 3β-Benzoyloxy-4-pregnen-16α,17α-epoxy-6,20-dione

research Crystal Structure and Synthesis of 3.BETA.-Benzoyloxy-4-pregnen-16.ALPHA.,17.ALPHA.-epoxy-6,20-dione

January 2004 in “Analytical Sciences: X-ray Structure Analysis Online”

The document explains how to make a compound called 3.BETA.-Benzoyloxy-4-pregnen-16.ALPHA.,17.ALPHA.-epoxy-6,20-dione and describes its crystal structure.

research Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives

March 2024 in “Organic letters”

A new method efficiently modifies alkenes to create useful medicinal compounds.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors and Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

research Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

9 citations , May 2021 in “Molecules”

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations , September 2000 in “Journal of Medicinal Chemistry”

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

Monocyclic Aromatic Compounds: Synthesis and Biological Activities

research Monocyclic Aromatic Compounds

1 citations , March 2007

Monocyclic aromatic compounds are important for developing various drugs and treatments.

research Crystal Structure of 17-.BETA.-Benzoyloxy-16-.BETA.-methylpregna-4,6-diene-3,20-dione.

February 1999 in “Analytical Sciences”

A new antiandrogen compound was made and its detailed three-dimensional shape was described.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research Applications of steroid drugs entrapped in cyclodextrins

23 citations , March 2019 in “Environmental Chemistry Letters”

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

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