18 citations
,
September 2021 in “Colloids and surfaces. B, Biointerfaces” Nanoparticles can effectively deliver spironolactone to hair follicles for treating alopecia and acne.
18 citations
,
May 2020 in “Biomolecules” Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.
17 citations
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August 2001 in “Australasian journal of dermatology” A woman's liver problems improved after she stopped taking spironolactone.
17 citations
,
April 1997 in “Archives of dermatology” The document describes a treatment for excessive hair growth in a teenage girl using medication and birth control, but does not report the results.
17 citations
,
January 1986 in “Acta obstetricia et gynecologica Scandinavica” Spironolactone can reduce hair growth and testosterone in hirsutism, but is less effective than combined treatments.
17 citations
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October 2013 in “Der Hautarzt”
16 citations
,
January 1987 in “Dermatology” The spironolactone cream did not reduce hair growth in women with hirsutism.
15 citations
,
April 2020 in “Journal of The American Academy of Dermatology” Spironolactone effectively treats female pattern hair loss with few side effects.
13 citations
,
February 2022 in “JAMA Dermatology” Spironolactone does not increase cancer risk and may lower prostate cancer risk, but more research is needed.
12 citations
,
December 2002 in “Fertility and Sterility” Spironolactone plus finasteride works better for treating hirsutism.
12 citations
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April 1987 in “PubMed” Low-dose spironolactone is safe and effective for treating hirsutism.
11 citations
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September 2022 in “Journal of the Endocrine Society” Young transgender, gender diverse, and nonbinary people on spironolactone have a low risk of high potassium, so frequent monitoring may not be needed.
11 citations
,
October 2019 in “Cancers” Spironolactone may make some cancer treatments more effective by blocking a protein that helps cancer cells survive.
11 citations
,
July 2019 in “The Journal of Sexual Medicine” Spironolactone might cause painful intercourse and decreased sexual arousal in women.
10 citations
,
December 2020 in “Dermatologic Therapy” Minoxidil and spironolactone combo effectively treats androgenetic alopecia, improving hair density and diameter.
10 citations
,
May 2020 in “Journal of The American Academy of Dermatology” Taking spironolactone doesn't increase the chance of breast cancer coming back.
10 citations
,
September 2015 in “Gynecological Endocrinology” Both treatments reduced excessive hair growth in PCOS, but there was no difference in weight, hair score, hormone levels, or insulin resistance.
9 citations
,
June 2021 in “International Journal of Pharmaceutics” Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.
9 citations
,
June 2020 in “Trials” The trial aims to test if spironolactone is an effective acne treatment for women without the side effects of current treatments.
9 citations
,
April 2011 in “PubMed” Spironolactone is used in dermatology to treat skin conditions related to hormones, but is not safe for pregnant women or men.
8 citations
,
September 2023 in “Advanced Pharmaceutical Bulletin” Chitosan-coated spironolactone nano carriers effectively treat acne without side effects.
8 citations
,
March 2022 in “International Journal of Endocrinology” Combining spironolactone with metformin reduces insulin resistance in PCOS better than either drug alone.
8 citations
,
August 2021 in “PubMed” Oral spironolactone effectively treats hair loss with mild, manageable side effects.
8 citations
,
August 2020 in “Clinical and Experimental Dermatology” Spironolactone is a low-cost, effective, and generally safe treatment for various skin conditions related to hormones.
8 citations
,
April 1988 in “Journal of endocrinological investigation” Topical spironolactone cream doesn't cause hormone-related side effects in the body.
7 citations
,
January 1990 Spironolactone improved hair density and quality in women with hair loss.
6 citations
,
April 2013 in “Journal of Investigative Dermatology” Spironolactone might lower the chance of getting rosacea.
6 citations
,
November 1993 in “Contact dermatitis” Spironolactone in anti-acne cream can cause allergic skin reactions in some people.
6 citations
,
January 1984 in “PubMed” Spironolactone treatment reduced hair growth and androgen levels in hirsute women, but the overall effectiveness was just adequate.
5 citations
,
December 2020 in “Journal of The American Academy of Dermatology” Minoxidil and spironolactone improve hair density and reduce shedding in girls.