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Androgenetic Alopecia: Relationship to Anthropometric Indices, Blood Pressure and Life-Style Habits

13 citations , February 2020 in “Clinical, Cosmetic and Investigational Dermatology”

Men with hair loss have higher BMI, waist size, blood pressure, and are linked to smoking and inactivity.

Early Embryonic Exposure of Freshwater Gastropods to Pharmaceutical 5-Alpha-Reductase Inhibitors Results in a Surprising Open-Coiled 'Banana-Shaped' Shell

research Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell

13 citations , November 2019 in “Scientific reports”

Certain drugs change freshwater snail shells to a "banana" shape.

research Finasteride and androgenic alopecia; from therapeutic options to medical implications

13 citations , March 2019 in “Journal of Dermatological Treatment”

Finasteride can treat hair loss, but may have side effects; evaluate and inform patients of risks.

Morpho-Regulation in Diverse Chicken Feather Formation: Integrating Branching Modules and Sex Hormone-Dependent Morpho-Regulatory Modules

research Morpho‐regulation in diverse chicken feather formation: Integrating branching modules and sex hormone‐dependent morpho‐regulatory modules

13 citations , December 2018 in “Development, Growth & Differentiation”

Sex hormones, especially estradiol, can change chicken feather shapes and colors.

Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice

research Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice

13 citations , August 2018 in “Journal of Molecular and Cellular Cardiology”

Finasteride improves heart function and repairs damage after heart attack in mice.

research Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression

12 citations , May 2016 in “British Journal of Dermatology”

AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

11 citations , December 2018 in “Assay and Drug Development Technologies”

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

research
Dihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines

11 citations , September 2020 in “OncoTargets and Therapy”

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

research Experimental and early investigational drugs for androgenetic alopecia

11 citations , July 2017 in “Expert Opinion on Investigational Drugs”

New hair loss treatments may include topical medications, injections, and improved transplant methods.

research Metabolic dysfunction in female mice with disruption of 5α-reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function

11 citations , August 2014 in “Current Urology Reports”

Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.

Androgenetic Alopecia: Overview, Epidemiology, Pathophysiology, and Treatment

research Androgenetic alopecia

11 citations , September 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

Various treatments exist for hair loss, but more research is needed for better options.

Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

research Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

11 citations , November 2012 in “Seminars in Cutaneous Medicine and Surgery”

Genetic factors affect hair loss, and molecular testing may help predict, diagnose, and treat it.

Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

research Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway

10 citations , May 2019 in “BMC Complementary and Alternative Medicine”

The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

research Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses

10 citations , February 2019 in “Toxicological Sciences”

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

research Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats

10 citations , May 2018 in “Neuropharmacology”

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Changes in Serum Free Testosterone, Sleep Patterns, and 5-Alpha-Reductase Type I Activity Influence Sebum Excretion in Female Subjects

research Changes in serum free testosterone, sleep patterns, and 5‐alpha‐reductase type I activity influence changes in sebum excretion in female subjects

10 citations , August 2014 in “Skin research and technology”

Sleep, testosterone levels, and a specific enzyme activity affect skin oil production in women.

research Finasteride

10 citations , June 2010 in “Expert Opinion on Drug Metabolism & Toxicology”

Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.

Prolongation of Off-Cycle Interval by Finasteride Is Not Associated with Survival Improvement in Intermittent Androgen Deprivation Therapy in LNCaP Tumor Model

research Prolongation of off-cycle interval by finasteride is not associated with survival improvement in intermittent androgen deprivation therapy in LNCaP tumor model

9 citations , September 2009 in “The Prostate”

Finasteride doesn't improve survival in LNCaP tumor model during off-cycle of therapy.

Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

research Research Brief: Self-Reports of a Constellation of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

9 citations , January 2018 in “American Journal of Men's Health”

Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.

Increased DHT Levels in Androgenic Alopecia Selected to Protect Men from Prostate Cancer

research Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer

9 citations , January 2014 in “Medical Hypotheses”

Higher DHT in male baldness may protect against prostate cancer.

research Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss

9 citations , November 2012 in “Archives of Dermatological Research”

MC4R gene variants not linked to female hair loss.

research Transcriptomic profiling in Silurana tropicalis testes exposed to finasteride

8 citations , February 2014 in “General and Comparative Endocrinology”

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

research Anti-androgenic therapy with finasteride in patients with chronic heart failure – a retrospective propensity score based analysis

7 citations , July 2019 in “Scientific Reports”

Finasteride helps reduce heart enlargement in heart failure patients.

research The diagnosis of androgenetic alopecia in children: Considerations of pathophysiological plausibility

7 citations , June 2019 in “Australasian Journal of Dermatology”

AGA in children needs careful diagnosis due to low androgen levels and possible other causes.

research Novel ABCD1 Gene Mutation in Adrenomyeloneuropathy with Hypoplasia and Agenesis of the Corpus Callosum

7 citations , January 2018 in “Neurodegenerative Diseases”

Researchers found a new ABCD1 gene mutation linked to a rare brain and nerve disorder with unusual brain changes.

Circulating and Intraprostatic Sex Steroid Hormonal Profiles in Relation to Male Pattern Baldness and Chest Hair Density Among Men Diagnosed with Localized Prostate Cancers

research Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers

7 citations , October 2017 in “The Prostate”

Baldness in men with prostate cancer is linked to higher levels of certain sex hormones, but chest hair density is not.

research Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

7 citations , January 2015 in “Dermatology”

Two gene variations, rs6493497 and rs7176005, may be linked to female hair loss in Chinese people.

research Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome

6 citations , October 2018 in “Endocrinology”

Prenatally androgenized ewes can model increased hair diameter in women with PCOS.

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