2295 citations
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August 2012 in “The international journal of transgenderism/International journal of transgenderism” The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.
1549 citations
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March 2006 in “Science” Understanding stem cell interactions with their environments is key for advancing regenerative medicine.
1279 citations
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November 2005 in “Nature Medicine”
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
815 citations
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April 2010 in “The Journal of Clinical Endocrinology & Metabolism” Women with PCOS should be screened for heart disease risk and manage their health to prevent it.
721 citations
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October 2011 in “Nature” Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.
717 citations
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June 2010 in “Nature” Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
688 citations
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June 2007 in “Cell Stem Cell” Removing the ATR gene in adult mice causes rapid aging and stem cell loss.
578 citations
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May 1996 in “Plant Cell & Environment” Low phosphorus makes Arabidopsis thaliana grow longer root hairs.
555 citations
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July 2001 in “Genes & Development” Tcf3 and Lef1 are key in deciding skin stem cell roles.
550 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
506 citations
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March 2005 in “The Journal of Clinical Endocrinology and Metabolism” Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.
503 citations
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May 2009 in “Cell stem cell” Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.
499 citations
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September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
480 citations
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August 2014 in “Nature Biotechnology” Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.
467 citations
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October 2014 in “European Journal of Endocrinology” The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.
451 citations
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March 2005 in “Endocrine Reviews” The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
425 citations
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June 2020 in “Nature” Scientists created human skin with hair from stem cells, which could help treat hair loss and skin conditions.
425 citations
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August 2002 in “BioEssays” The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.
421 citations
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September 2003 in “Development” Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.
414 citations
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August 2005 in “Nature” Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.
402 citations
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August 2011 in “Cancer research” Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
396 citations
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May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
387 citations
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November 2003 in “Journal of Investigative Dermatology” The K15 promoter effectively targets stem cells in the hair follicle bulge.
384 citations
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June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
375 citations
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July 2006 in “Journal of Investigative Dermatology” Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.
365 citations
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March 2021 in “Frontiers in Bioengineering and Biotechnology” Nanocarriers can improve drug delivery through the skin by overcoming barriers.
363 citations
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March 2017 in “Nature Communications” Stem cells help heal wounds by rapidly dividing and migrating to the wound edge.