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research Effects of non-contingent cocaine on 3alpha-androstanediol. I. Disruption of male sexual behavior
Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.
research Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata
Steroids help hair regrowth, and minoxidil slows post-steroid hair loss, but effects are temporary.
research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids
A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.
research Expanding the therapeutic versatility of clacosterone
Clascoterone cream could be used for other skin conditions affected by hormones.
research News & Notes
Loop diuretics may double bone loss in elderly men, finasteride lowers prostate cancer risk but may increase high-grade tumors, abarelix reduces testosterone quickly, and transdermal testosterone offers minimal sexual benefit for women.
research Testosterone replacement in the setting of Finasteride therapy: a therapeutic dilemma
research Farmácia Boa Hora - Porto
Minoxidil and spironolactone can improve hair growth, but responses vary and side effects are common.
research Testosterone, cytochrome P450, and cardiac hypertrophy
Heart-specific steroid metabolism is crucial in cardiac hypertrophy.
research Efektivitas Terapi Minoksidil pada Alopesia Androgenetik: Studi in Vivo
5% minoxidil significantly increases hair follicle density.
research Latanoprost and minoxidil: Comparative double-blind, placebo-controlled study for the treatment of hair loss
Latanoprost and minoxidil effectively control hair loss and increase hair count.
research Dihydrotestosterone induces arterial stiffening in female mice
Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.
research Studies on Neurosteroids XXV. Influence of a 5.ALPHA.-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism
Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.
research Effect of 3-Beta Hydroxysteroid Dehydrogenase on Serum Testosterone Level in Obese Women With Polycystic Ovary Syndrome
3βHSD2 is not useful for diagnosing PCOS.
research Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.
Finasteride and minoxidil together promote hair growth better than either alone.
research The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms
Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.
research EFFECT OF LOW DOSE FINASTERIDE ON SEMEN VOLUME AND SPERM DENSITY IN YOUNG MEN
research Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry
The method effectively measures drug impact on DHT levels in prostate treatments.
research Systemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata
Prednisone can regrow hair in alopecia areata, and minoxidil helps maintain it.
research AN EFFICIENT SYNTHESIS OF DUTASTERIDE: UTILIZING BENZOYL GROUP AS NOVEL LACTAMIC PROTECTING GROUP
Researchers created a new, efficient way to make Dutasteride, a hair loss and prostate drug, with high purity using a benzoyl group.
research Drug safety evaluation of exemestane
Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
New compounds called benzoquinolinones may treat conditions linked to excess DHT.
research Allopregnanolone promotes proliferation and differential gene expression in human glioblastoma cells
Allopregnanolone increases growth and changes gene activity in human brain cancer cells.
research Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque
Taking finasteride pills and using minoxidil lotion together can help grow hair.
research 11-oxyandrogen Concentrations in Adolescents With Polycystic Ovary Syndrome (PCOS)
Adolescents with PCOS have higher levels of certain androgens, which are linked to hair growth but don't help diagnose PCOS better than testosterone levels.
research 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors
The document's conclusion cannot be provided because the document is not available or cannot be read.
research Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry
Rodent models of PCOS show some hormone changes similar to humans, but also have key differences.
research The effect of St John’s wort on the pharmacokinetics and metabolism of finasteride in man
research Beneficial effect of spironolactone on androgenic alopecia
Spironolactone may help reduce hair loss in androgenic alopecia.
research Determination Method for Steroid 5α-Reductase Activity Using Liquid Chromatography/Atmospheric Pressure Chemical Ionization–Mass Spectrometry
A new method was developed to measure and assess the activity and inhibition of the enzyme steroid 5α-reductase.