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GlossaryStearoyl-CoA Desaturase 1

enzyme converting saturated fatty acids to monounsaturated fatty acids

Stearoyl-CoA Desaturase 1 (SCD1) is an enzyme that plays a crucial role in the metabolism of fatty acids. It converts saturated fatty acids into monounsaturated fatty acids, which are important for maintaining cell membrane fluidity and producing signaling molecules. This enzyme is significant in various biological processes, including lipid metabolism and energy homeostasis, and has been linked to conditions like obesity, diabetes, and certain skin disorders.

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research Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 ^-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

87 citations , March 2007 in “Biological Chemistry”

Deleting the scd1 gene in mice prevents obesity by disrupting skin lipids and improving heat regulation.

research Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

67 citations , December 2013 in “Journal of Biological Chemistry”

SCD1 is crucial for skin health and overall energy balance.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

research Scd1 ab-Xyk : a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse

12 citations , July 2004 in “Molecular genetics and genomics”

A new mouse mutation causes skin and hair defects due to a gene change.

research Skin Stearoyl-CoA Desaturase Genes

1 citations , January 2013

research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

71 citations , January 2014 in “Journal of Proteome Research”

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

research Differentiation of the sebaceous gland

60 citations , March 2009 in “Dermato-Endocrinology”

The exact molecular mechanisms of sebaceous gland function are still unclear.

research SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

4 citations , December 2022 in “Advanced science”

SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.

research Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis

4 citations , February 2018 in “Journal of Investigative Dermatology”

The document concludes that a protein involved in hair growth may link to baldness and that more research is needed on its role in hair loss and skin cancer treatments.

research Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche

March 2023 in “Scientific reports”

Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.

research 1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity

5 citations , April 2014 in “Journal of Lipid Research”

SCD1 inhibitors can cause skin issues in rodents.

research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

22 citations , August 2013 in “Experimental Dermatology”

EGFR hyperactivation increases sebaceous gland size and sebum production in mice.

research Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia

14 citations , October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5

18 citations , June 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

A gene called Gk5 controls lipid production in the skin and affects hair growth.

research 666 Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in follicular dystrophy and primary cicatricial alopecia

April 2018 in “Journal of Investigative Dermatology”

Mutations in Far2 mice cause hair loss due to sebaceous gland issues.

research The acyl-CoA binding protein is required for normal epidermal barrier function in mice

31 citations , July 2012 in “Journal of Lipid Research”

ACBP is crucial for healthy skin in mice.

research Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

5 citations , February 2025 in “Cell Reports”

Skin acetyl-CoA synthesis is crucial for overall lipid balance.

research Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers

33 citations , March 2013 in “Journal of Investigative Dermatology”

Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.

research Characterization of Hair Follicle Development in Engineered Skin Substitutes

41 citations , June 2013 in “PLOS ONE”

Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.

research Serum irisin: A prognostic marker for severe acne vulgaris

8 citations , September 2018 in “Journal of Cosmetic Dermatology”

Lower irisin levels in the blood may indicate more severe acne.

Cystathionine Beta-Synthase-Deficient Mice Thrive on a Low-Methionine Diet

research Cystathionine β‐synthase‐deficient mice thrive on a low‐methionine diet

28 citations , November 2013 in “The FASEB journal”

Mice with CBS deficiency are healthier on a low-methionine diet.

research Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice

19 citations , July 2015 in “Journal of inherited metabolic disease”

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

Overview of Lichen Planopilaris: Diagnosis and Treatment

research Lichen Planopilaris

July 2018 in “Elsevier eBooks”

Lichen Planopilaris is a hair loss condition best treated early with various medications, including hydroxychloroquine, to prevent permanent baldness.

Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

research Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

6 citations , August 2014 in “Toxicologic pathology”

Blocking DGAT1 reduces oil gland size in mice and dogs, but only mice experience hair loss.

Molecular Interactions of Natural and Synthetic Steroids in Female Hamsters’ Flank Organs

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations , October 2010 in “The American Journal of Pathology”

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

research The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

134 citations , January 2011 in “Development”

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.