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GlossaryStem Cell Activation

process stimulating dormant cells to divide and specialize

Stem cell activation refers to the process by which dormant stem cells are stimulated to begin dividing and differentiating into specialized cell types. This is crucial for tissue repair and regeneration, as well as for maintaining healthy hair growth. In the context of hair, activating stem cells in hair follicles can potentially reverse conditions like alopecia by promoting the growth of new hair.

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Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.

research Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine

13 citations , January 2021 in “RSC chemical biology”

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

research The incidental pore: Ca_V1.2 and stem cell activation in quiescent hair follicles

3 citations , June 2013 in “Genes & development”

CaV1.2 helps activate hair follicle stem cells without calcium flux.

Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

1 citations , September 2012 in “Journal of Investigative Dermatology”

Aging reduces stem cell activation, leading to hair loss in mice lacking a specific enzyme.

research Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation.

May 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

A balance between BMP and Wnt signals is crucial for hair follicle stem cell function and hair growth.

research 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification

1 citations , April 2018 in “Journal of Investigative Dermatology”

PRC1 is essential for proper skin development and stem cell formation by controlling gene activity.

Activation of Olfactory Receptor 2A4/7 by Cyclohexyl Salicylate Promotes Human Hair Follicle Growth

research 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion

November 2022 in “Journal of Investigative Dermatology”

The fragrance cyclohexyl salicylate helps promote hair growth and increase hair stem cell numbers.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

research LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis

1 citations , July 2024 in “Journal of Investigative Dermatology”

Immune cells boost stem cell activity in hairy moles, causing more hair growth.

research Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

182 citations , May 2003 in “Development”

Myc activation reduces skin stem cells by affecting cell adhesion.

research mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration

71 citations , January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis

January 2024

Autophagy helps activate hair stem cells and hair growth by changing their energy use to glycolysis.

research Lactate dehydrogenase activity drives hair follicle stem cell activation

202 citations , August 2017 in “Nature cell biology”

Lactate production is important for activating hair growth stem cells.

research Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration

30 citations , February 2017 in “Histochemistry and Cell Biology”

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

research RETRACTED: Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers

6 citations , October 2014 in “International Journal of Molecular Sciences”

Tanshinone IIA helps protect tissue from low oxygen damage by activating certain cell pathways.

HPV8 E6 Induced STAT3 Activation Leads to Hair Follicle Junctional Zone Keratinocyte Stem Cell Proliferation and Expansion in Actinic Keratoses

research 277 HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

HPV8 causes hair follicle stem cells to grow, leading to skin lesions.

research TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population

9 citations , January 2015 in “Medical hypotheses”

TCDD disrupts skin stem cells, causing skin issues like chloracne.

research Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth

34 citations , April 2018 in “EMBO journal”

The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.

research Decision letter: Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells

July 2017

IL-1 signaling is crucial for hair follicle stem cell growth and wound healing.

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway

research Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway

August 2025 in “Stem Cell Research & Therapy”

Exosomes from stem cells can help regrow hair better than minoxidil.

research Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation

176 citations , January 2013 in “Proceedings of the National Academy of Sciences”

BMP and Wnt signaling balance controls hair follicle stem cell activity and hair growth.

research miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

30 citations , August 2021 in “Oncogene”

miR-22 helps skin cancer grow and spread by activating specific cell signals.

Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia

research Retinoic acid drives hair follicle stem cell activation via Wnt/β‐catenin signalling in androgenetic alopecia

April 2024 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Retinoic acid helps activate hair growth in people with common hair loss by working on a specific cell growth pathway.

research Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis

June 2023 in “Research Square (Research Square)”

Autophagy, a cell process, helps activate hair growth stem cells and promote hair growth by controlling glycolysis, a type of cell metabolism.

Natural Product Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration

research Natural product Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration

May 2023 in “Research Square (Research Square)”

Shi-Bi-Man activates hair follicle stem cells and promotes hair growth by changing lactic acid metabolism and other cellular processes.

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

BMP signaling prevents hair growth by stopping stem cell activation.

research Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

117 citations , March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

research Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

6 citations , April 2022 in “Journal of diabetes research”

Type 2 diabetes slows down skin and hair renewal by blocking important stem cell activation in mice.