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GlossaryStem Cell Differentiation

process where unspecialized cells become specialized cell types

Stem cell differentiation is the process by which unspecialized stem cells develop into specialized cells with distinct functions, such as skin cells, muscle cells, or nerve cells. This process is crucial for growth, development, and tissue repair, as it allows the body to generate the specific cell types needed for various functions and structures.

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research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations , January 2014 in “BioMed research international”

Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.

research Abstract 5219: The role of MEK and Antizyme in keratinocyte stem cell expansion and differentiation

1 citations , April 2012 in “Cancer Research”

Antizyme reduces tumor growth and normalizes skin cell development affected by MEK.

Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS

research Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS

9 citations , March 2019 in “Scientific reports”

Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.

Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair

research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair

46 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.

research Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro

24 citations , February 2015 in “Experimental Cell Research”

NFIC helps human dental stem cells grow and become tooth-like cells.

research 576 A preliminary study of melanogenic markers in the differentiation of the human hair follicle melanin unit

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study found markers indicating that cells responsible for hair color are differentiating in specific areas of the hair follicle.

research Early-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells

6 citations , July 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Younger mice's hair-follicle stem cells are better at turning into heart cells than older mice's.

research CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties

41 citations , April 2019 in “PLOS genetics”

CD34+ and CD34- melanocyte stem cells have different regenerative abilities.

research 1360 Fate tracing of DNA-damaged hair follicle stem cells and their seno-differentiation clearance out of the niche

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Damaged hair follicle stem cells may leave the skin to help maintain youthfulness.

$Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation$

research Human keratinocytes derived from the bulge region of hair follicles are refractory to differentiation

8 citations , April 2009 in “International journal of oncology”

Hair follicle cells resist turning into skin cells.

research 136 Physiological function of Krox20 (Egr2) in epithelial stem cells

April 2021 in “Journal of Investigative Dermatology”

Krox20 is crucial for hair growth and maintaining skin stem cells.

Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles

research Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

6 citations , July 2022 in “World journal of stem cells”

Using extracellular vesicles from stem cells can help hair grow by affecting scalp cells and hair follicles.

research Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

31 citations , April 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.

research Biochemistry of epidermal stem cells

26 citations , July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

research Impaired differentiation potential of CD34-positive cells derived from mouse hair follicles after long-term culture

2 citations , June 2022 in “Scientific reports”

Mouse hair follicle stem cells lose their ability to change into different cell types after being grown for a long time.

research Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

253 citations , March 1994 in “Developmental dynamics”

Apoptosis is essential for human skin development and forming a functional epidermis.

Human Skin Stem Cells and the Aging Process

research Human skin stem cells and the ageing process

143 citations , September 2008 in “Experimental gerontology”

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

research The in vitro plasticity of hair follicle dermal and mesenchymal stem cells

January 2008 in “Durham e-Theses (Durham University)”

Hair follicle stem cells are similar to mesenchymal stem cells and can become neural-like cells under certain conditions.

research Epidermal keratinocyte stem cells: their maintenance and regulation

25 citations , December 1992 in “Seminars in cell biology”

Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.

research Differentiation of nestin-negative human hair follicle outer root sheath cells into neurons in vitro

5 citations , January 2017 in “Molecular Medicine Reports”

Human hair follicle cells can be turned into neural stem cell-like cells, which might help treat brain diseases.

research Twist1 is required for the development of UVB‐induced squamous cell carcinoma

11 citations , March 2021 in “Molecular Carcinogenesis”

Twist1 is crucial for UVB-induced skin cancer development.

research 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific mutation in the TRPV3 gene causes hair follicle cells to develop improperly, leading to hair loss.

$Isolation of Adipose-Derived Stem Cells Using a Subfractionation Culturing Method$

research Isolation of adipose-derived stem cells by using a subfractionation culturing method

17 citations , July 2014 in “Expert Opinion on Biological Therapy”

The new method for isolating stem cells from fat is simple and effective, producing cells that grow faster and are better for hair regeneration.

research In vitro Differentiation of Adipose-Derived Stem Cells into Hair Cell-Like Cells in Guinea Pigs

3 citations , December 2007 in “Journal of Otology”

Guinea pig fat stem cells can become hair cell-like cells in a lab.

research Hair follicle stem cells:In vitroandin vivoneural differentiation

25 citations , January 2015 in “World journal of stem cells”

Hair follicle stem cells can become different cell types and may help treat neurodegenerative disorders.

research FGF20 Secreted From Dermal Papilla Cells Regulate the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine‐Wool Sheep

3 citations , December 2024 in “Journal of Animal Physiology and Animal Nutrition”

FGF20 is essential for hair follicle stem cell growth and development in fine-wool sheep.

research The Progress of Epidermal Stem Cell Research

January 2010

Epidermal stem cells help renew skin and heal wounds, influenced by specific proteins and markers.

Nestin as a Marker of Unipotent Epithelial Progenitor Cell Differentiation into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles

May 2022 in “Research Square (Research Square)”

Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.

research Expression of the hair stem cell-specific marker nestin in epidermal and follicular tumors.

35 citations , December 2008 in “PubMed”

Trichilemmoma, BCC, and SCC tumors have different stem cell marker expressions.

research Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB

19 citations , September 2013 in “Molecular Medicine Reports”

Human hair follicle stem cells can become smooth muscle cells using specific growth factors.