research The therapeutic promise of apoptosis
Blocking cell death in certain stem cells can improve wound healing and tissue regeneration.
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research Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls
Hair growth environment recreated with challenges; stem cells make successful skin organoids.
research PBX1-SIRT1 positive feedback loop attenuates ROS-mediated HF- MSC senescence and apoptosis
PBX1 reduces aging and cell death in stem cells by boosting SIRT1 and lowering PARP1.
research Stem cells, organoids and their applications for human diseases: Special issue of BMB Reports in 2023
Organoids created from stem cells are used to model diseases, test drugs, and develop personalized and regenerative medicine.
research Aging Skin: A Window to the Body
Skin aging reflects overall body aging and can indicate internal health conditions.
research RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies
Advances in RNA research and skin models offer hope for better skin healing without scarring.
research Embryologic layers in dermatology: Developmental checkpoint disorders, diagnostic insight, and regenerative futures
Understanding embryologic layers improves skin disorder diagnosis and supports developing targeted therapies.
research Editors' Picks
Activin increases skin tumor formation, skin Tregs help hair growth, lymph-node removal doesn't improve melanoma survival, cells can revert to stem cells in wound healing, and skin bacteria produce peptides that may treat infections.
research Stem Cells in the Skin
The skin has different types of stem cells that can repair and regenerate tissue.
research Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death
Zebrafish helped find new ways to prevent drug-induced hair cell death and potential treatments for hearing loss.
research Any route for melanoblasts to colonize the skin!
Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.
research Tooth tissue and organ regeneration using stem cells
Stem cell-based therapies can regenerate and replace teeth effectively.
research Regenerative medicine in aesthetic surgery: Hope or hype?
Regenerative medicine shows promise for aesthetic surgery, but needs more research for widespread use.
research The Hair Follicle as a Dynamic Miniorgan
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
Wnt signaling is crucial for skin development and hair growth.
research Cell fate decisions: emerging roles for metabolic signals and cell morphology
Metabolic signals and cell shape influence how cells develop and change.
research The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine
The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.
research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4
Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
research From neural crest cells to melanocytes: cellular plasticity during development and beyond
Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.
research Emerging nonmetabolic functions of skin fat
Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
research Small molecules and small molecule drugs in regenerative medicine
Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.
research Therapeutic Potential of Stem Cells in Follicle Regeneration
Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.
research Functional hair follicle regeneration: an updated review
Hair follicle regeneration possible, more research needed.
research Tuning Wnt Signals for More or Fewer Hairs
Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
research Immune modulation of hair follicle regeneration
Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.
research What does acne genetics teach us about disease pathogenesis?
Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.
research Deciphering principles of morphogenesis from temporal and spatial patterns on the integument
The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.
research Sorafenib stimulates human skin type mast cell degranulation and maturation
Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.
research Aging of hair follicle stem cells and their niches
Aging changes hair stem cells and their environment, leading to gray hair and hair thinning, but understanding these changes could help develop treatments for hair regeneration.
research Advances in genetic and molecular understanding of Omenn syndrome - implications for the future
Newborn screening and gene therapy are expected to improve outcomes for Omenn syndrome patients.