RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies
May 2026
in “
Life
”
RNA coding transcriptional regulation skin repair fibrotic scarring regeneration transcriptomic profiling gene-regulatory programs keratinocytes fibroblasts immune cells RNA-mediated networks miRNAs lncRNAs epithelial migration inflammation resolution stem cell-derived skin organoids engineered skin models regenerative strategies microRNAs long non-coding RNAs skin organoids
TLDR Advances in RNA research and skin models offer hope for better skin healing without scarring.
This review examines the role of RNA-mediated networks in skin repair, focusing on the potential of organoid-based regenerative strategies. It highlights the influence of protein-coding and non-coding RNAs, such as miRNAs and lncRNAs, on processes like epithelial migration and inflammation resolution. The document discusses the promise of stem cell-derived skin organoids in preclinical settings, noting their ability to create complex skin structures, including hair follicles. However, it emphasizes that these strategies remain hypothetical and unproven in humans, with challenges like regulatory requirements and patient-specific customization needing to be addressed before clinical application.
