January 2015 in “Springer eBooks” Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.
92 citations
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March 2016 in “Developmental Cell” Zebrafish skin regeneration relies on cell behaviors and reactive oxygen species, with antioxidants reducing and hydrogen peroxide increasing regeneration.
64 citations
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August 2013 in “Mayo Clinic Proceedings” Wound healing insights can improve regenerative medicine.
33 citations
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September 2008 in “Biochemical and Biophysical Research Communications” Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.
27 citations
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September 2018 in “Nanomedicine: Nanotechnology, Biology and Medicine” Further research is needed to improve hair regeneration using stem cells and nanomaterials.
19 citations
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January 2013 in “Frontiers in Neuroanatomy” Zebrafish can help study and develop treatments for hearing loss.
759 citations
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February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
414 citations
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August 2005 in “Nature” Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.
316 citations
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June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
146 citations
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July 2018 in “Regenerative Medicine” Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.
127 citations
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January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
113 citations
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June 2015 in “Stem Cell Research & Therapy” Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
112 citations
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January 2014 in “Molecular and cellular therapies” Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
105 citations
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December 2017 in “Journal of Biological Engineering” Artificial skin grafts face immune rejection, but stem cells may improve future designs.
97 citations
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September 2016 in “Reviews in Endocrine and Metabolic Disorders” The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
92 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.
90 citations
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July 2020 in “Stem Cell Research & Therapy” Stem cell vesicles can reduce skin aging from UVB by lowering inflammation and oxidative stress.
72 citations
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January 2023 in “International Journal of Biological Sciences” Engineered exosomes show promise for improving wound healing but face challenges in clinical use.
70 citations
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February 2015 in “Expert Opinion on Drug Discovery” Topical drugs and near-infrared light therapy show potential for treating alopecia.
68 citations
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September 2018 in “Trends in Cell Biology” Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.
66 citations
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July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
64 citations
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July 2016 in “Cold Spring Harbor Perspectives in Medicine” The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
64 citations
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August 2007 in “Artificial Organs” PHBV nanofiber matrices help wounds heal faster when used with hair follicle cells.
61 citations
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June 2014 in “Scientific Reports” Wnt1a-conditioned medium from stem cells helps activate cells important for hair growth and can promote hair regrowth.
60 citations
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April 2012 in “Physiology” The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.
58 citations
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November 2013 in “Journal of Innovative Optical Health Sciences” Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
57 citations
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March 2011 in “The American Journal of Dermatopathology” Chemotherapy can cause permanent, non-reversible hair loss similar to pattern baldness.
44 citations
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July 2020 in “Stem Cell Research & Therapy” Epidermal stem cells show promise for skin repair and regeneration.
42 citations
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February 2021 in “Signal Transduction and Targeted Therapy” Hair follicle regeneration possible, more research needed.
38 citations
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February 2016 in “Surgery Journal” Facial plastic surgery has evolved to focus on less invasive techniques and innovative technologies for cosmetic and reconstructive procedures.