July 2024 in “Journal of Investigative Dermatology” Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.
December 2009 in “Cancer Research” Over-expression of Sp2 can lead to cancer by preventing proper stem cell differentiation.
2 citations
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March 2022 in “Laboratory Animal Research” A mild botulinum toxin injection improved sperm production and movement in aging mice.
11 citations
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July 2015 in “Frontiers in Cellular Neuroscience” Corticosterone makes ethanol more effective at blocking brain processes important for learning and memory.
80 citations
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September 2007 in “Cell Cycle” Stem cells in hair follicles can become various cell types, including neurons.
14 citations
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December 1998 in “The Journal of Clinical Endocrinology and Metabolism” MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.
1 citations
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May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The fer-ts mutation in plants prevents root hair growth at high temperatures.
77 citations
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February 2017 in “Stem Cell Reports” SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.
October 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Activating telomerase can boost hair follicle stem cell growth and hair production.
321 citations
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March 2015 in “Nature” Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.
3 citations
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April 2016 in “Research and reports in urology” The new saw palmetto extract effectively inhibits an enzyme linked to prostate enlargement and may be as good as standard treatments.
14 citations
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February 2018 in “Psychoneuroendocrinology” Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
22 citations
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November 2017 in “Scientific Reports” The pituitary gland functions normally even after losing most SOX2+ stem cells.
2 citations
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April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.
31 citations
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September 2013 in “Stem Cells” Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.
23 citations
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September 2013 in “Molecular Carcinogenesis” Increased Stat3 activity reduces hair follicle stem cells and boosts other stem/progenitor cells.
124 citations
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July 1997 in “Journal of Biological Chemistry” Overexpressing a specific enzyme in mice causes hair loss and female infertility.
April 2018 in “Journal of Investigative Dermatology” Hair follicle stem cells can change their role to ensure proper hair development.
3 citations
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July 2017 in “Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model” Mouse hair follicle stem cells have a flexible chromatin state that supports skin health and hair growth.
April 2023 in “Journal of Investigative Dermatology” Changing YBX1 protein activity affects skin stem cell function and aging.
3 citations
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August 2023 in “Biophysical Journal” Mitochondrial activity varies in cells before they stop growing, affecting their growth potential.
421 citations
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September 2003 in “Development” Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.
17 citations
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May 2021 in “Journal of Cell Science” N1-acetylspermidine promotes hair follicle stem cell self-renewal.
13 citations
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March 1999 in “Biochemical Journal” Overexpressing SSAT in mice makes them highly sensitive to polyamine analogues, causing liver damage and high mortality.
54 citations
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May 2001 in “Journal of Investigative Dermatology” Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.
16 citations
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February 2018 in “BMC Genomics” Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.
November 2022 in “Journal of Investigative Dermatology” Aging in one type of stem cell can cause aging-like changes in various organs.
October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” A small BOTOX dose improved sperm production and movement in older mice.
August 2013 in “eCommons (Cornell University)” Runx1 and CDK inhibitors help keep hair follicle stem cells inactive, affecting their future roles.
45 citations
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August 2023 in “Trends in Cell Biology” Controlling cellular changes can enable safe rejuvenation without cancer risk.