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LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Sphingosine 1-phosphate affects inflammation and gene expression in different aorta cells.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.

The substance MK386 effectively blocked testosterone conversion and reduced cell growth in certain skin cells, but inhibiting 5α-reductase alone may not greatly improve acne.

Researchers developed reliable models to predict how well certain compounds bind to androgen receptors, emphasizing the importance of atomic electronegativity.

Progesterone reduces anxiety without needing progesterone receptors.

Neurosteroids help balance brain signals when certain inhibitions are reduced.

A new method accurately measures nine specific hormones in human blood.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Certain substances can decrease or increase exploratory behavior in rodents.

Ethosomes with 30% ethanol effectively deliver dutasteride to hair follicles for treating hair loss.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

Jute leaves may help reduce DHT levels, potentially aiding in conditions like hair loss and prostate issues.

Ethosomes improve drug delivery through the skin but may have side effects like irritation.

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

Male and female Gynostemma longipes plants have significant chemical differences.

Progesterone boosts alcohol's effect on brain, finasteride counters it.

Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Breathing in newborn rats is affected differently by hormones based on their sex.

A rigid compound with a common structural motif was successfully synthesized.

Neurosteroid withdrawal increases α4 subunit expression in the hippocampus, which may relate to catamenial epilepsy in women.